Deep Inspiration Breath-hold Radiotherapy for Left-sided Breast Cancer
- Conditions
- Breast CancerCardiac Event
- Interventions
- Device: Deep inspiration breath-hold technique
- Registration Number
- NCT05200078
- Lead Sponsor
- Shu lian Wang
- Brief Summary
Postoperative breast radiotherapy (RT) has been associated with increased risk of heart toxicity. However, there is a lack of knowledge for radiation-induced early cardiovascular injury, especially for hypofractionated RT. This study aims to prospectively detect and predict early clinical or subclinical cardiac events in women undergoing adjuvant RT for breast cancer.
- Detailed Description
Women with left-sided breast cancer undergo hypofractionated RT at either free-breathing or deep inspiration breath-hold. The incidence and potential clinical, dosimetric and biological indicators of early clinical or subclinical cardiac injury are investigate at 2 years.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 166
Inclusion Criteria
- Primary left-sided breast cancer post surgery
- Planning for adjuvant breast/chest wall +-RNI
Exclusion Criteria
- History of cardiovascular disease
- Previous chest radiation
- Bilateral breast cancers
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Radiotherapy at deep inspiration breath-hold Deep inspiration breath-hold technique breast/chest wall+-RNI 43.5Gy/15f/3w（tumor bed 49.5Gy/15f/3w) delivered at deep inspiration breath-hold
- Primary Outcome Measures
Name Time Method Incidence of clinical or subclinical cardiac injury two years predefined cardiac events
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Cancer Hospital, Chinese Academy of Medical Sciences
🇨🇳Beijing, China