A study to compare the strength of dexmedetomidine and lignocaine in protecting old people from suffering loss in intelligence after undergoing surgery.
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Elderly patients in the age group of 60-80 undergoing any open abdominal surgery irrespective of the type of surgery.
- Registration Number
- CTRI/2018/08/015358
- Lead Sponsor
- Dr Mahendran T Kurup
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
1 Age from 60-80 years.
2 Males or Females.
3 ASA grade I and II.
4 Minimum educational level till fifth standard.
5 Undergoing any open abdominal surgery of two hours or more.
Exclusion Criteria
1 Refusal to consent for being a part of the study.
2 Any known allergy to the intervention drugs.
3 Any history of psychiatric or neurologic disorders or previous neurosurgeries
4 Any uncontrolled systemic disease causing an adverse effect on the cognitive function of the patient.
5 Intra-operative profound hypotension or any complication warranting stopping of the intervention agents.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The incidence of POCD in both the drug intervention groups. <br/ ><br>POCD being defined as a fall of more than or equal to 20% in the post-operative neuropsychological test scores as compared to the pre-operative scores. <br/ ><br>Timepoint: Post-Operative day 3 <br/ ><br> <br/ ><br> <br/ ><br>
- Secondary Outcome Measures
Name Time Method Changes in the serum levels of IL-1,IL-6,TNF-alpha & <br/ ><br>S-100 beta <br/ ><br>postoperative as compared to preoperative values.Timepoint: post-operative day 3