The impact of dietary nitrate supplementation on exercise-induced cardiac troponin T release in type 2 diabetic patients: a pilot-study

Completed

• Conditions: exercise-induced cTnT release; exercise-induced heart damage; 10011082; 10012653

• Registration Number: NL-OMON37028
• Lead Sponsor: Human Movement Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

-type 2 diabetes
-exercise-induced rise in cardiac troponin T (>3 ng/L)

Exclusion Criteria

-HbA1c <6.0% or >10.0%
-diagnosed impaired renal or liver function
-morbid obesity (BMI>35 kg/m2)
-incident cardiovascular events in the last year (heart attack, stroke, aneurysms)
-treatment with medication which contain nitrates and/or having vasodilatory effects

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>cTnT levels at baseline and over the subsequent 6 h period following exercise</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Plasma nitrate and plasma nitrite concentrations<br /><br>Blood pressure measured at 8:00, 9:30, 10:00, 10:30, 11:00, 12:15, 14:00 and<br /><br>16:00 h.<br /><br>Orthogonal polarization spectroscopy (OPS) will be applied at 8:00, 10:00,<br /><br>11:00 and 13:30 and 16:00 h. This non-invasive method has proven to quantify<br /><br>microvascular flow and endothelium permeability for erythrocytes in the oral<br /><br>cavity.</p><br>