Efficacy of Dexmedetomidine as an adjuvant to 0.25% Bupivacaine in Ultrasound guided Femoral Nerve Block for Pre-operative positioning and Post-operative Analgesia in patients undergoing elective surgery for Femoral shaft fracture
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- To determine patient comfort for positioning for spinal anaesthesia and Duration of post operative analgesia
研究概览
简要总结
FemoralNerve Block,(FNB) a type ofregional anaesthesia providesfor reduction in pain intensity in the Peri-operative period allowing for easypositioningandextending analgesia postoperatively, thereby reducing the need for opioids.
Various adjuvant drugs suchas epinephrine, opioids, Sodium Bicarbonate,midazolam, ketamine, and neostigmine have been evaluated in conjunction withlocal anesthetics to prolong the duration of analgesia, but they were found tobe either ineffective or to produce an unacceptably high incidence of adverse effects.
Dexmedetomidine isa selective α2 adrenoceptor agonist has an Analgesic, Anaesthetic sparing effect, Symphatholytic, Sedative, Cardiovascular stabilizing property. Not many studies have been performed using it as an adjuvant to femoral nerve block, hence a study to know its effectiveness as an adjuvant is being planned.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA Grade I & II.
排除标准
- •1 Allergy to Study Drug 2 History of significant systemic disease ( n Cardiovascular, Respiratory, Central Nervous System, Renal System ) 3 Cognitive Dysfunction 4 Emergency Surgeries 5 Patients with Spinal Deformities, Bleeding Diasthesis 6 Local Skin Site Infection 7 Refusal by patients for procedure.
结局指标
主要结局
To determine patient comfort for positioning for spinal anaesthesia and Duration of post operative analgesia
时间窗: From start of procedure until 24 hrs post operative
次要结局
- 1 Onset, Duration, Level of sensory Block(2 Onset, Duration of motor Block)