To determine if addition of Dexmedtomidine to Bupivacaine used in Femoral Nerve Block will enhance duration of post operative analgesia

Phase 4

Completed

Conditions: Fracture of shaft of femur,

Registration Number: CTRI/2020/07/026467

Lead Sponsor: Vijayanagara Institute of Medical Sciences

Brief Summary: **FemoralNerve Block**,**(FNB)** a type ofregional anaesthesia providesfor reduction in pain intensity in the Peri-operative period allowing for easypositioningandextending analgesia postoperatively, thereby reducing the need for opioids.

Various adjuvant drugs suchas epinephrine, opioids, Sodium Bicarbonate,midazolam, ketamine, and neostigmine have been evaluated in conjunction withlocal anesthetics to prolong the duration of analgesia, but they were found tobe either ineffective or to produce an unacceptably high incidence of adverse effects.

**Dexmedetomidine** isa selective Î±2 adrenoceptor agonist has an Analgesic, Anaesthetic sparing effect, Symphatholytic, Sedative, Cardiovascular stabilizing property. Not many studies have been performed using it as an adjuvant to femoral nerve block, hence a study to know its effectiveness as an adjuvant is being planned.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 70

Inclusion Criteria

ASA Grade I & II.

Exclusion Criteria

1 Allergy to Study Drug 2 History of significant systemic disease ( n Cardiovascular, Respiratory, Central Nervous System, Renal System ) 3 Cognitive Dysfunction 4 Emergency Surgeries 5 Patients with Spinal Deformities, Bleeding Diasthesis 6 Local Skin Site Infection 7 Refusal by patients for procedure.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine patient comfort for positioning for spinal anaesthesia and Duration of post operative analgesia	From start of procedure until 24 hrs post operative

Secondary Outcome Measures

Name	Time	Method
1 Onset, Duration, Level of sensory Block	2 Onset, Duration of motor Block

Trial Locations

Locations (1): Vijayanagara Institute of Medical Sciences
🇮🇳
Bellary, KARNATAKA, India
Vijayanagara Institute of Medical Sciences
🇮🇳Bellary, KARNATAKA, India
Dr Vinod M
Principal investigator
9902375272
vinodm9092@gmail.com