ISRCTN75746444已完成不适用
Assessment of efficacy and saftey of vaginal acidity enhancement with 3% acetic acid on response to vaginal misoprostol induction of abortion in missed mid-trimesteric abortion
Ain Shams University Maternity Hospital (Egypt)0 个研究点目标入组 48 人开始时间: 2011年1月10日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 48
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- Female
入选标准
- •1. Aged 18 - 40 years
- •2. Missed abortion
- •3. Singleton pregnancy
- •4. Gestational age ranging between 14 and 26 weeks of pregnancy (by calculation, examination and/or ultrasound)
- •5. Uterus and cervix apparently normal on clinical examination
- •6. Cervix not dilated with absence of effacement
- •7. Absence of uterine activity
- •8. Written and signed informed consent by the patient to participate in the study
排除标准
- •1. A contraindication to medical termination of pregnancy, e.g. placenta praevia
- •2. Evidences suggesting onset of spontaneous abortion (uterine contractions with or without cervical changes)
- •3. Presence of vaginal bleeding
- •4. Presence of intrauterine contraceptive device (IUCD) in situ
- •5. Presence of ruptured membranes and/or suspicion of septic abortion as evidenced by maternal temperature of 38°C or more, uterine tenderness or foul-smelling vaginal discharge
- •6. Previous trial to induce abortion or the use of pre-induction agent during the current pregnancy
- •7. Any contraindication to receiving prostaglandins, including known hypersensitivity to misoprostol or other prostaglandins (PGs), history of asthma, glaucoma, cardiac or cardiovascular disease
- •8. Parity six or more
- •9. Multifetal pregnancy
- •10. Polyhydramnios
- •11. Uterine anomaly, previous two or more caesarean sections, previous uterine surgery, e.g., myomectomy or trauma, e.g., uterine perforation
- •12. History of any cervical surgery or manipulation: cervical cerclage during current pregnancy history thereof during a previous pregnancy, previous cauterization of cervical erosion, previous cervical dilatation or operation with resultant apparent cervical tears or lacerations
- •13. Associated collagen or autoimmune medical disorder
- •14. Metabolic acidosis as a result of a medical disorder
- •15. History of adverse effects to vaginally administered medications
- •16. Likelihood of requiring treatment during the study period with drugs not permitted by the study protocol which include all vaginal forms of medications
- •17. Mental condition rendering the patients unable to understand the nature, scope and possible consequences of the study
研究者
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