The Effects of Tirzepatide Use on Muscle and Vascular Function Among Obese Older Adults
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Appendicular lean muscle mass
研究概览
简要总结
Obesity and type 2 diabetes mellitus (T2DM) represent major public health concerns in the aging community. Tirzepatide, a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist recently approved for the treatment of T2DM and obesity has been shown to be effective at reducing weight, improving markers of T2DM control, and improving cardiovascular health. Utilization of tirzepatide among older adults has been on the rise since FDA approval was issued, however the effects of tirzepatide use on functional outcomes in older adults with obesity are not well established. Recent studies show that weight loss caused by tirzepatide may be driven by substantial loss of lean muscle mass, which may contribute to weakness and frailty, particularly among older adults. The proposed pilot study aims to evaluate how treatment with tirzepatide for 6 months affects muscle mass and function among older adults, and if changes in muscle mass are linked to changes in functional status over the same time period.
详细描述
This study is a pilot, single-arm, open-label clinical trial to evaluate the effects of Tirzepatide on muscle mass, strength, and vascular health among older adults with obesity. This study is set in South Texas, where rates of obesity and related health issues, including type 2 diabetes and cardiovascular conditions, exceed national averages and where aging-related diseases are on the rise. Tirzepatide is a new FDA approved medication that promotes weight loss and improves health by targeting specific pathways in the body. While it has been shown to be effective in managing weight and blood sugar levels, there is less information about the kind of weight loss it induces, and how weight loss impacts measures of muscle mass, strength and mobility. This is especially concerning for older adults, as losing muscle mass can lead to weakness, falls, and disability.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men and postmenopausal women aged 50 years or older.
- •Body Mass Index (BMI) ≥30 kg/m².
- •Untreated HbA1c <6.5% at baseline.
- •Willingness and ability to comply with all study procedures, including fasting requirements for certain visits.
- •Able to provide informed consent and participate in all study assessments.
排除标准
- •Active diagnosis of type 2 diabetes mellitus (T2DM), defined by active use of glucose-lowering medications or hemoglobin A1c ≥ 6.5%.
- •Body Mass Index (BMI) ≥ 40 kg/m².
- •Moderate to severe gastroesophageal reflux disease based on patient history.
- •Inability to comply with the treatment protocol or to understand the consent form.
- •Chronic Kidney Disease (CKD) Stage
- •Aspartate aminotransferase (AST) > 33 U/L or alanine aminotransferase (ALT) > 36 U/L.
- •Active pregnancy.
- •Personal or family history of medullary thyroid carcinoma.
- •Personal or family history of multiple endocrine neoplasia type 2 syndrome.
- •Personal history of gastroparesis.
- •Personal history of diabetic retinopathy.
- •Known serious hypersensitivity, including anaphylaxis and angioedema, to Tirzepatide or any of its excipients.
- •Known serious hypersensitivity, including anaphylaxis and angioedema, to any GLP-1 receptor agonist class of therapies.
- •Concomitant treatment with GLP-1 receptor agonist therapy
研究组 & 干预措施
Tirzepatide
Tirzepatide self-administered once weekly by subcutaneous injection
干预措施: Tirzepatide (Drug)
结局指标
主要结局
Appendicular lean muscle mass
时间窗: 6 months
Appendicular lean muscle mass assessed at baseline and at 6-month follow-up by dual-energy X-ray absorptiometry (DEXA)
Muscle Strength
时间窗: 6 months
Muscle strength assessed by isokinetic and isometric testing using Biodex dynamometry at baseline and at 6-month follow-up.
Lower Extremity Functional Capacity
时间窗: 6 months
Functional capacity will be measured using the 6-minute walk test (6MWT) at baseline and 6-month follow up visit.
次要结局
未报告次要终点
研究者
Shreya Rao
Assistant Professor
The University of Texas Health Science Center at San Antonio