Does anterior cruciate ligament (ACL) injury impair the molecular pathways responsible for building muscle?

Not Applicable

Completed

Conditions: Anterior Cruciate Ligament injury
Injuries and Accidents - Other injuries and accidents
Musculoskeletal - Other muscular and skeletal disorders

Registration Number: ACTRN12622001166763

Lead Sponsor: Assoc Prof David Opar

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 12

Inclusion Criteria

1.Male or female
2.Aged between 18 to 35 years
3.One leg sustained an ACL injury within the last 5-years, but can safely complete lower limb strength training
4.BMI 18.5-29.9m2

Exclusion Criteria

1.Any lower limb injury in the past 24-months that influences the quadriceps responses to exercise (e.g. muscle strain)
2.Known cardiovascular disease or diabetes
3.Known bleeding disorder (i.e. hemophilia A [factor VIII deficiency], hemophilia B [factor IX deficiency], von Willebrand disease, or other rare factor deficiencies including I, II, V, VII, X, XI, XII and XIII)
4.Major or chronic illness that impairs mobility or eating/digestion
5.Taking prescription medications (i.e. beta-blockers, anti-arrhythmic drugs, statins, insulin sensitising drugs, or drugs that increase the risk of bleeding [i.e. anticoagulants, antiplatelets, novel oral anticoagulants [NOAs], nonsteroidal anti-inflammatory drugs [NSAIDs], selective norepinephrine reuptake inhibitors [SNRI], or selective serotonin reuptake inhibitors [SSRIs])

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Activation of key strength training signalling pathways measured with quadriceps muscle biopsy [ Measured during the strength training session, immediately before and after exercise];Skeletal muscle protein content as measured with quadriceps muscle biopsy[ Measured during the strength training session, immediately before and after exercise]

Secondary Outcome Measures

Name	Time	Method
ower limb muscle morphology as measured by a 3-Tesla (3T) magnetic resonance imaging system. Contiguous T1-weighted axial MRIs (transverse relaxation time: 2500 ms; echo time: 14ms; field of view: 220 x 360 mm; slice thickness: 5mm; interslice distance: 0mm) will be taken of both limbs, beginning at T12, L1 intersection and finishing distal to the malleoli.[ Measured during the MRI scan session, prior to the strength training session. ];Leg press 1-repetition maximum (1RM). [ Measured during the familiarisation session. ]