Coronary Vasomotor Function in Myocardial Infarction with NonObstructive Coronary Arteries (MINOCA)

The University of Adelaide0 个研究点目标入组 40 人开始时间: 2018年9月13日最近更新: 2021年1月5日

适应症

试验速览

暂无简介。

•1) Patients presenting with the symptoms suggestive of acute non-ST elevation myocardial infarction (NSTEMI) will be approached to participate in this study.
•2) Male/Female, Aged equal or above 18 years
•3) Acute MI Criteria (Must meet both of the following criteria (a & b)
•a) Troponin I or T level greater than the 99th percentile of the upper reference limit (URL)
•b) No significant ST segment elevation in ECG
•4) Coronary angiography diagnosis of non-obstructive coronary arteries ( less than 50% stenosis or completely normal arteries)

•1) ST-segment elevation on ECG (ie: STEMI)
•2) Thrombolytic therapy within 48 hours of diagnostic angiography.
•3) Troponin elevation due to non-ischaemic causes identified prior to coronary angiography
•4) Coronary angiography revealing obstructive coronary arteries (above or equal to 50% stenosis)
•5) Severe valvular disease – including aortic stenosis (valve gradient more than 50mmHg) mitral regurgitation (regurgitation extending to pulmonary veins), mitral stenosis (valve are less than 1cm2)
•6) Significant left ventricular dysfunction as documented by an ejection fraction less than 40%
•7) Severe obstructive airways – any prior admission to ICU or general hospital admission in past 12 months for infective exacerbation of airways disease.
•8) Active internal bleeding or history of hemorrhagic diathesis (including heparin-induced thrombocytopenia)
•9) Major surgery (eg: CABG) or trauma within the previous 6 weeks
•10) Non-English speaking
•11) Pregnancy
•12) Inability to provide informed consent (Compromised mental status, e.g., dementia, too ill)
•13) Currently a prisoner
•14) Contraindications to drugs and devices (Adenosine, GTN, OCT wire, Combo wire)

发起方