Coronary Vasomotor Function in Myocardial Infarction with NonObstructive Coronary Arteries (MINOCA)

The University of Adelaide0 sites40 target enrollmentSeptember 13, 2018

Overview

No summary available.

Registry

who.int

Start Date

September 13, 2018

End Date

TBD

Last Updated

5 years ago

Study Type

Observational

Sex

All

Sponsor

•1\) Patients presenting with the symptoms suggestive of acute non\-ST elevation myocardial infarction (NSTEMI) will be approached to participate in this study.
•2\) Male/Female, Aged equal or above 18 years
•3\) Acute MI Criteria (Must meet both of the following criteria (a \& b)
•a) Troponin I or T level greater than the 99th percentile of the upper reference limit (URL)
•b) No significant ST segment elevation in ECG
•4\) Coronary angiography diagnosis of non\-obstructive coronary arteries ( less than 50% stenosis or completely normal arteries)

•1\) ST\-segment elevation on ECG (ie: STEMI)
•2\) Thrombolytic therapy within 48 hours of diagnostic angiography.
•3\) Troponin elevation due to non\-ischaemic causes identified prior to coronary angiography
•4\) Coronary angiography revealing obstructive coronary arteries (above or equal to 50% stenosis)
•5\) Severe valvular disease – including aortic stenosis (valve gradient more than 50mmHg) mitral regurgitation (regurgitation extending to pulmonary veins), mitral stenosis (valve are less than 1cm2\)
•6\) Significant left ventricular dysfunction as documented by an ejection fraction less than 40%
•7\) Severe obstructive airways – any prior admission to ICU or general hospital admission in past 12 months for infective exacerbation of airways disease.
•8\) Active internal bleeding or history of hemorrhagic diathesis (including heparin\-induced thrombocytopenia)
•9\) Major surgery (eg: CABG) or trauma within the previous 6 weeks
•10\) Non\-English speaking