Calcium balance during haemodiafiltration and high flux haemodialysis

Completed

• Conditions: Renal; Urological and Genital Diseases

• Registration Number: ISRCTN51182136
• Lead Sponsor: Royal Free Hospital (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-11-01
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

1. Thrice weekly haemodialysis or haemodiafiltration
2. Ability to provide informed consent
3. Serum total calcium within laboratory normal reference range
4. Reliably functioning vascular access for dialysis

Exclusion Criteria

1. Unable to provide informed consent
2. Aged 18 to 85 years
3. ECG with prolonged QTc
4. History of life-threatening cardiac arrhythmias
5. Recent myocardial infarction within previous 3 months
6. Admission to hospital for change in vascular access
7. Unlikely to survive 6 months
8. Planned living donor transplant
9. Patients with history of missing dialysis sessions

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine whether there is a difference in calcium balance between haemodialysis and haemodiafiltration treatments. Calcium balance will be measured by comparing the amount of calcium delivered in the dialysate and that recovered in the spent dialysate, and the calcium flux (difference between the two) compared to measurements of calcium, and other electrolytes in blood tests at the start and end of calcium and parathyroid hormone concentrations.

Secondary Outcome Measures

Name	Time	Method
Sodium and other electrolyte balance, changes in blood pressure and fluid removal and ECG changes