Effects of Light Emitting Diode Irradiation on the Conduction Parameters of the Superficial Radial Nerve

Not Applicable

Completed

Brief Summary: The introduction of light emitting diode (LED) devices as a novel treatment for pain relief in place of low-level laser warrants fundamental research on the effect of LED devices on one of the potential explanatory mechanisms: peripheral neurophysiology in vivo. A randomized controlled study will be conducted by measuring nerve conduction on the superficial radial nerve of healthy subjects (n=64). One baseline measurement and five post-irradiation recordings (2-min interval each) will be performed of the nerve conduction velocity (NCV) and peak latency (PL) and peak amplitude (PA). The experimental group (=32) will receive an irradiation of 2 J/cm2 with an infrared LED device (Dynatronics Solaris Model 705), while the placebo group will be treated by sham irradiation. The purpose of this study is to investigate the effects of LED light on the conduction velocity and amplitude of the superficial radial nerve.

Recruitment & Eligibility

Inclusion Criteria

no history of neurological disease, polyneuropathy, peripheral neuropathy or cervical radiculopathy

Exclusion Criteria

positive findings during the clinical screening examination suggestive of an underlying neurological disease, polyneuropathy, peripheral neuropathy or cervical radiculopathy.
a history of a neurological disease, polyneuropathy, peripheral neuropathy or cervical radiculopathy.

Arm && Interventions

Group	Intervention	Description
Superluminous Light Diode Irradiation	Superluminous light diode	Application of super luminous diodes light irradiation over the superficial radial nerve
Sham Superluminous Light Diode Irradiation	Superluminous light diode	Sham Superluminous Light Diode Irradiation over the Superficial Radial Nerve for the same time period as the intervention group

Primary Outcome Measures

Name	Time	Method
Nerve Conduction Velocity (Meters Per Second)	pre-treatment, 0 min, 2 min, 4 min, 6 min, 8 min and 10 min after treatment	Change in nerve conduction velocity (m/s) from pre-treatment to 0 minute (immediately after treatment), and at 2 min intervals after treatment until 10 minutes post treatment occurs. Calculated difference scores at each time point = nerve conduction velocity (NCV) - baseline NCV. A positive variance represented an increase from baseline and is interpreted as being an increase or faster velocity.

Secondary Outcome Measures

Name	Time	Method
Temperature (Degrees C)	pre-treatment, 0 min, 2 min, 4 min, 6 min, 8 min and 10 min after treatment	Change in superficial skin temperature (degrees C) from pre-treatment to 0 minute (immediately after treatment), and at 2 min intervals after treatment until 10 minutes post treatment occurs. Calculated difference scores at each time point = Temperature - Temperature at baseline. A positive variance int his calculation can be interpreted as being an increase from baseline or an increase in skin temperature
Negative Peak Latency (Milliseconds)	pre-treatment, 0 min, 2 min, 4 min, 6 min, 8 min and 10 min after treatment	Change in negative peak latency (ms) from pre-treatment to 0 minute (immediately after treatment), and at 2 min intervals after treatment until 10 minutes post treatment occurs. Calculated difference scores at each time period = negative peak latency NPL - baseline NPL. A positive variance can be interpreted as being increase from baseline or a prolonged or slowed NPL.