Multi-centre European study of major infectious disease syndromes - Arboviral compatible febrile illness

Recruiting

• Conditions: Arboviral compatible febrile illness; Infections and Infestations

• Registration Number: ISRCTN74074706
• Lead Sponsor: niversity of Oxford

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-01-21
• Last Update Posted: 14 January 2019
• Study Completion: 2020-01-05

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 1500

Inclusion Criteria

1. Adults (= 18 years old) admitted to hospital from 1st May – 31st October inclusive with recent onset (<21 days) of symptoms of suspected Encephalitis or Meningitis .

OR

2. Rapid onset of temp.= 38°C of unknown etiology (<21 days) AND at least ONE of the signs or symptoms below:
2.1. A neurological symptom (such as: neck stiffness, photophobia, partial paralysis, polyradiculitis, periorbital pain, confusion, altered mental state)
2.2. Severe headache
2.3. Myalgia
2.4. Backache
2.5. Arthralgia
2.6. Maculopapular rash
2.7. Haemorrhagic symptom
2.8. Thrombocytopenia (<150 000 cells per microliter of blood)

Exclusion Criteria

1. Patients with non-infectious central nervous system (CNS) disorders due to hypoxic, vascular, toxic or metabolic causes
2. Patients where the symptoms are due to another confirmed cause, such as bacterial infection, malaria, malignancy, immune disorders, trauma
3. Patients with a focal source of infection identified, such as pneumonia, viral respiratory tract infection, acute infectious diarrhea, urinary tract infection (positive urine cultures), or skin or soft-tissue infection
4. Patients where the symptoms are caused by recurrence of a pre-existing condition

Study & Design

• Study Type: Observational
• Study Design: Not specified