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Clinical Trials/NCT04828642
NCT04828642CompletedNot Applicable

Vitamins C and Vitamin E and Hypertrophy Adaptations to Resistance Traini

Universidad Europea de Madrid2 sites in 1 country30 target enrollmentStarted: February 1, 2021Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
30
Locations
2
Primary Endpoint
Manual dinamometry

Study Overview

Brief Summary

This investigations aims to investigate whether supplementation with antioxidant vitamins (vitamin C and vitamin E) can influence, enhancing or blocking, the hypertrophic adaptations caused by strength training in sedentary subjects.

Detailed Description

A randomized, double-blind, placebo-control controlled trial will be conducted. In a previous session volunteers will be interviewed to determine if they meet the inclusion criteria. Will be done two weeks of flushing out other types of supplementation and strenuous physical exercise, along with familiarization with the strength training program and performance tests to be carried out during the rehearsal. Subsequently, it will be a week without exercising to start with the experimental designs. From the start of the trial, participants should avoid physical exercise. strenuous outside the training protocol and if usual, they will only be able to perform one resistance training session per week. Participants should avoid ingesting of foods that contain high amounts of antioxidant compounds: more than two juices of fruits, more than four cups of coffee or tea. Juices with high antioxidant content should be avoided. Alcoholic beverages should also be avoided.

  • Group 1 (G1): Antioxidant vitamins (VitC (1000 mg) + VitE (235 mg)) + exercise
  • Group 2 (G2): Placebo + exercise A supplementation period of 12 weeks will be carried out. In each period, supplementation with antioxidant vitamins: VitC (1000 mg) + VitE (235 mg) or with placebo.

All participants will ingest the supplementation between 1-3 hours before training, the days of rest in the mornings.

All participants will perform a 12-week strength training protocol. The training session performed in the sharp design will be the first training session in chronic design. Being the baseline (E0) and post-exercise (E1) assessment performed in G1, G2 and G3 also the first evaluation corresponding to the chronic design.

In the middle of the supplementation period (week 6) and at the end, two new evaluations (week 12). Baseline evaluations will be performed prior to an exercise session of week 6 (E2) and at the last exercise session (E3) of the following parameters: performance physique, body composition, micronutrient analysis, muscle ultrasound. I also know conduct post-exercise physical performance assessments Figure 2.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Basic Science
Masking
Double (Participant, Investigator)

Masking Description

The provider will produce the supplementation and the placebo with the same aspect, marked with numbers

Eligibility Criteria

Ages
18 Years to 30 Years (Adult)
Sex
Male
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Experience in strength training of at least one year

Exclusion Criteria

  • Antioxidant supplementation
  • Injuries or diseases

Outcomes

Primary Outcomes

Manual dinamometry

Time Frame: Week 5

Handgrip

DOMS

Time Frame: Week 10

Delayed onset muscle soreness evaluated with visual analoguic scale (0 no pain- 10 maximal pain)

RPE

Time Frame: Week 10

10-point scale (no exertion 0- maximal effort 10)

Anthropometry

Time Frame: Week 10

Evaluation of muscle mass by a ISAK 1 level anthropometrist

Leg dinamometry

Time Frame: Week 10

Dinamometer

Parameters determined by ENCODER

Time Frame: Week 10

Bench press and squats

DEXA

Time Frame: Week 10

Evaluation of muscle mass with dual energy X-ray absorptiometry

Bioimpedance

Time Frame: Week10

Evaluation of muscle mass with an Inbody

1 RM

Time Frame: Week 10

Bench press and squats

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
Universidad Europea de Madrid
Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

María Martínez Ferrán

predoctoral researcher

Universidad Europea de Madrid

Study Sites (2)

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