Methylene blue Versus Vasopressin as Second Line Vasopressor in Septic Shock- A Randomized Controlled Trial - NI

All India Institute Of Medical Sciences New Delhi0 个研究点目标入组 0 人开始时间: 待定最近更新: 2024年8月19日

试验速览

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•Adult patients with septic shock requiring norepinephrine support of =0.2 µg/kg/min for a minimum of 30 minutes despite fluid resuscitation with a minimum of 20 ml/kg to maintain mean arterial pressure (MAP) =65 mm Hg

•1.Patients with allergy to methylene blue
•2.Patients with known Glucose-6-phosphate dehydrogenase (G6PD) deficiency
•3.Patients with familial history of G6PD deficiency
•4.Patients with known haemolytic anaemia
•5.Patients with severe acute respiratory distress syndrome (ARDS)
•6.Pregnant and lactating women
•7.Patients with concurrent haemorrhagic or obstructive shock
•8.Patients with acute kidney injury KDIGO grade 3, pre-existing chronic renal disease
•9.Patients with pre-existing chronic liver disease
•10.Patients with coronary artery disease
•11.Patients on MAO inhibitors and selective serotonin re-uptake inhibitors
•12.Patients who have already been administered either of the two study drugs at any point during the disease

发起方

All India Institute Of Medical Sciences New Delhi