Role of exercise in chronic liver disease patients undergoing liver transplantation.
- Conditions
- Health Condition 1: K721- Chronic hepatic failure
- Registration Number
- CTRI/2023/10/058220
- Lead Sponsor
- Institute of Liver and Biliary Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Voluntary adult patient ( >18 years), decompensated chronic liver disease patients planned for LDLT, and Who pass the screening tests done in the OPD
1. Able to follow the introductory level exercises as per the protocol in the OPD without any adverse event.
2. No drop in the spO2 less than 93% on a 6 minute walk test.
1. Patients with a physical disability (upper or lower limb deformity/ abnormality)
2. Exercise intolerance or inability to follow exercise regime.
3. Patients who fail the screening tests.
4. Patients on the following drugs-
o Higher corticosteroid dose ( >0.1mg/kg/day),
o BCAA (Branched chain amino acids)
o Growth hormone, testosterone, SARMs,
o Ghrelin agonists, myostatin antibodies,
o Activin IIR antagonists, angiotensin converting enzyme inhibitors,
o Espindolol (mixed beta agonist and antagonists), and
o Fast skeletal muscle troponin activators.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method iver frailty index (Grip strength, Balance, Chair Stand test) <br/ ><br>Pulmonary function tests <br/ ><br>After 4 weeks of exercise- PFT <br/ ><br>Post operative time- PEF & FEV1. (Hand held machine) <br/ ><br>Physical performance- SPPB (Balance, Chair stands, Gait speed)Timepoint: After 4 weeks of intervention, on POD 14 & 30
- Secondary Outcome Measures
Name Time Method <br/ ><br>Major surgical complications (CDC = grade 3) <br/ ><br>Pulmonary complications- Clinical evaluationTimepoint: During the course of hospital stay.;MortalityTimepoint: 90 Day;Myostatin levels in blood <br/ ><br>Skeletal muscle mass- L3SMITimepoint: Post intervention at 4 weeks & on POD14;Time to extubation, need for re-intubation <br/ ><br>Duration of NIV support, <br/ ><br>Timepoint: During the course of hospital stay.;Time to mobilization out of bed, <br/ ><br>Length of ICU stay, hospital stay <br/ ><br>Incidence of all septic complicationsTimepoint: During the course of hospital stay