Efficacy of Vonoprazan Based Dual and Triple Therapy for Patient With Helicobacter Pylori Infection

Not Applicable

Recruiting

• Conditions: H. Pylori Infection
• Interventions: Drug: Efficacy of Vonoprazan based dual therapy for naive patient with Helicobacter Pylori infection; Drug: Efficacy of Vonoprazan based triple therapy for naive patient with Helicobacter Pylori infection; Drug: Efficacy of PPI based triple therapy for naive patient with Helicobacter Pylori infection

• Registration Number: NCT07045688
• Lead Sponsor: Sohag University

Brief Summary

This study aims to assess Efficacy of vonoprazan based dual and triple therapy for naïve patient with Helicopacter Pylori infection in Sohag Government .

Detailed Description

Not available

Study Timeline

• Study Start: 2025-05-13
• Status Verified: 2025-06
• Study First Submitted: 2025-06-23
• Study First Submitted QC: 2025-06-23
• Last Update Submitted: 2025-06-23
• Study First Posted: 2025-07-01
• Last Update Posted: 2025-07-01
• Primary Completion: 2025-11-25
• Study Completion: 2025-11-25

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Age: >18 years old.
• H. pylori infection: Confirmed by histopathology or non-invasive tests (e.g., stool antigen test).

Exclusion Criteria

• Prior H. pylori treatment: Previous treatment for H. pylori infection.
• Allergies: Known allergies to study medications or components.
• Patients cannot finish treatment course.
• Patient missed follow up.
• Patients refusing or neglecting test of cure for H. pylori.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Efficacy of Vonoprazan based dual therapy for naive patient with Helicobacter Pylori infection	Efficacy of Vonoprazan based dual therapy for naive patient with Helicobacter Pylori infection	we assess the efficacy of Vonoprazan based dual therapy for eradication of Helicobacter Pylori infection in naive patient.
Efficacy of Vonoprazan based triple therapy for naive patient with Helicobacter Pylori infection	Efficacy of Vonoprazan based triple therapy for naive patient with Helicobacter Pylori infection	we assess the efficacy of Vonoprazan based triple therapy for eradication of Helicobacter Pylori infection in naive patient.
Efficacy of PPI based triple therapy for naive patient with Helicobacter Pylori infection	Efficacy of PPI based triple therapy for naive patient with Helicobacter Pylori infection	we assess the efficacy of proton pump inhibitors (PPI) based dual therapy for eradication of Helicobacter Pylori infection in naive patient.

Primary Outcome Measures

Name	Time	Method
efficacy medical treatment for eradication of Helicobacter Pylori infection in naive patient.	4 weeks after successful medical treatment	stool antigen for H. Pylori

Trial Locations

Locations (1)

Sohag University Hospital; 🇪🇬 Sohag, Egypt