NCT03055169已完成不适用
TCF7L2 Polymorphisms Influence on Glycemic Control in ICU Patients With Organ Failure
University Hospital, Lille5 个研究点 分布在 1 个国家目标入组 994 人开始时间: 2012年4月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 994
- 试验地点
- 5
- 主要终点
- value of the odds ratio associated with the relationship between a polymorphism TCF7L2 gene and the occurrence of hyperglycemia
研究概览
简要总结
This study evaluates the link between genetic polymorphisms as r7903146, rs12255372 of TCF7L2 gene and the risk of developing hyperglycemia during Intensive care unit stay
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •admission in ICU>48h
- •at least one organ dysfunction
排除标准
- •age< 18 years
- •pregnant women
- •admission less than 48h
结局指标
主要结局
value of the odds ratio associated with the relationship between a polymorphism TCF7L2 gene and the occurrence of hyperglycemia
时间窗: one year after inclusion
find a link between genetic polymorphism of TCF7L2 and the risk of developing hyperglycemia in intensive care patients with a least one organ dysfunction. the hyperglycemia is defined fasting glucose\> 1.26 g / l twice or need for treatment with insulin)
次要结局
- Changes in inflammatory markers(one year after inclusion)
- Insulin Resistance (HOMA)(one year after inclusion)
- Changes in serum lipid profile(one year after inclusion)
- Changes in liver enzymes(one year after inclusion)
研究者
研究点 (5)
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