A cross-over study on effect of continuous blue light exposure on the physiology of prefrontal cortex of the brain among healthy adults
Not Applicable
- Registration Number
- CTRI/2022/10/046591
- Lead Sponsor
- ishitha G
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. age between 18 to 35 years include both male and female
2.
literate
3. basic English proficiency
4. regular sleep
schedule for 7 to 8 hours where bedtime 10 to 11 pm and wakeup
time 6 to 7 am IST
5. global PSQI score less than or equal to
5
6. refractive error with corrected distance VA better than or
equal to 20/25 with a healthy retina
Exclusion Criteria
1. any ocular pathology
2. any psychological and neurological disorders, intake of drugs,
smoking, alcoholism, intake of caffeine >2 cups/day or >400 mg/day
3. any systemic illness
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method i. Sleep score using Global PSQI scoring (Good <br/ ><br>sleep indicates PSQI less than 5 and Poor sleep <br/ ><br>greater than 5) <br/ ><br>ii. Cognitive test using Mini-Cog (quantitative) <br/ ><br>(Normal: Score 3-5; Cognitive impairment: Score <br/ ><br>0-2) <br/ ><br>iii. Pre-frontal cortical responses using ERP <br/ ><br>(target P300 amplitude in µV and P300 latency in <br/ ><br>msec) while performing N-back task when <br/ ><br>exposed to Blue LED (in lux). <br/ ><br>iv. Protective efficacy of blue light blocking <br/ ><br>lenses I, II, and Placebo lens III when exposed to <br/ ><br>Blue LED.Timepoint: Baseline, before and after 30 min of blue light exposure, and after 30 min of exposure with blue blocking lenses.
- Secondary Outcome Measures
Name Time Method i. Protective efficacy of blue light blocking lenses <br/ ><br>I (Crizal Prevenncia), II (DuraVision BlueProtect), <br/ ><br>and Placebo lens III (Untinted) when exposed to <br/ ><br>Blue LEDTimepoint: 30 minutes of exposure to blue LED with each <br/ ><br>blue-blocking lens.