Examining the Effect of Piano Playing Training on Fine Motor Skills in Parkinson's Patients
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 入组人数
- 3
- 试验地点
- 2
- 主要终点
- Box and block test
研究概览
简要总结
Piano playing may provide an engaging and accessible setting for finger and wrist movement training. Moreover, it has been found effective for improving manual dexterity and upper-limb function in other neurologic disorders, such as stroke and additionally beneficial for cognitive and psychosocial support in Parkinson's disease. However, no study has examined the effect of piano playing on dexterity in Parkinson's disease. The aim of this study is to test the efficacy of a novel piano-based training program on fine motor function in patients with PD. Participants with Parkinson's disease will take part in an individually tailored 6-week piano training program, combining weekly supervised training sessions (6x60 min altogether), with three independent at-home weekly 30 minutes practice sessions (18x30 altogether). Participants will receive a piano MIDI keyboard for home use during the study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Idiopathic Parkinson's Disease patients
- •Hoehn and Yahr stages I to III
- •Self-reports of some dexterity difficulties
排除标准
- •Participation in an ongoing clinical study or clinical study within 30 days prior to this study
- •Atypical parkinsonian syndrome or secondary parkinsonism (e.g., due to drugs, metabolic neurogenetic disorders, encephalitis, cerebrovascular disease, or other degenerative disease), or other neurologic conditions influencing upper limb movement
- •Significant psychiatric symptoms or history
- •Significant or recent experience in piano playing (participants who are proficient piano players, or had studied piano for more than 3 years in the past, or for shorter periods in the last 5 years)
- •Other significant fine motor skills (e.g., high proficiency in playing another musical instrument, video games, etc.)
- •Mini Mental status examination (MMSE) score below 25
- •Significant sensory deficits, e.g., hearing or sight impairment
- •Unstable medical disorder
- •Significant postural or action tremor, moderate dyskinesia
结局指标
主要结局
Box and block test
时间窗: First meeting, last meeting (after 6 weeks)
Number of blocks that can be moved over a barrier using the hand / arm in one minute
9 Hole peg test
时间窗: First meeting, last meeting (after 6 weeks)
Time taken to insert 9 pegs into holes and then remove them
Synergy index
时间窗: First meeting, last meeting (after 6 weeks)
Calculated from a force ramp production task using the fingers with force sensors
Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS) motor parts II (patient questionnaire) - parts 2.4 to 2.7 and III (motor examination) - parts 3.3 and 3.4
时间窗: First meeting, last meeting (after 6 weeks)
Standard questionnaire used in Parkinson's disease. Higher scores indicate more impairment. Maximum score for each part is 4, so overall for the 6 parts the maximum score is 24.
次要结局
- Quantitative Digitography - Coefficient of variation of interval between strikes(First meeting, last meeting (after 6 weeks))
- Quantitative assessment of piano performance progress(First meeting, last meeting (after 6 weeks))
- Quantitative Digitography - Average strike duration(First meeting, last meeting (after 6 weeks))
- Quantitative Digitography - Coefficient of variation strike duration(First meeting, last meeting (after 6 weeks))
- Quantitative Digitography - Average interval between strikes (in seconds)(First meeting, last meeting (after 6 weeks))
研究者
Jason Friedman
Associate Professor
Tel Aviv University