CTRI/2012/04/002553
Completed
未知
Randomized Controlled Trial Comparing Two Different Regimes of Magnesium Sulphate in Severe Pre-eclampsia: A Pilot Study - PIPES Trial
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Health Condition 1: O141- Severe pre-eclampsiaHealth Condition 2: null- Women with Severe Pre-eclampsia
- Sponsor
- JIPMER
- Enrollment
- 402
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Any pregnant woman with Severe Pre\- eclampsia as per the ACOG Criteria:
- •oSystolic blood pressure of 160 mm Hg or higher or diastolic blood pressure of 110 mm Hg or higher on two occasions at least 6 hours apart.
- •oProteinuria of 5 gm or higher in a 24\-hour urine specimen or 3\+ or greater on two random urine samples collected at least 4 hours apart.
- •oOliguria of less than 500 ml in 24 hours.
- •oCerebral or visual disturbances
- •oPulmonary edema or cyanosis
- •oEpigastric or right upper\-quadrant pain
- •oImpaired liver function
- •oThrombocytopenia
- •oFetal growth restriction
Exclusion Criteria
- •oMultiple Pregnancy
- •oPlatelet count \< 50,000/mm3
- •oPlasma creatinine value \>\= 2mg/dl
- •oComatose patients
- •oDeranged coagulation profile
- •oKnown case of myasthenia gravis
- •oKnown case of seizure disorder
- •oPatients with Eclampsia (defined as presence of new\-onset grand mal seizures in a woman with preeclampsia).
- •oHypersensitivity to Magnesium.
- •oWomen who have received have received magnesium sulphate therapy before being referred.
Outcomes
Primary Outcomes
Not specified
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