Randomized Controlled Trial Comparing Two Different Regimes of Magnesium Sulphate in Severe Pre-eclampsia: A Pilot Study - PIPES Trial

JIPMER0 个研究点目标入组 402 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•Any pregnant woman with Severe Pre- eclampsia as per the ACOG Criteria:
•oSystolic blood pressure of 160 mm Hg or higher or diastolic blood pressure of 110 mm Hg or higher on two occasions at least 6 hours apart.
•oProteinuria of 5 gm or higher in a 24-hour urine specimen or 3+ or greater on two random urine samples collected at least 4 hours apart.
•oOliguria of less than 500 ml in 24 hours.
•oCerebral or visual disturbances
•oPulmonary edema or cyanosis
•oEpigastric or right upper-quadrant pain
•oImpaired liver function
•oThrombocytopenia
•oFetal growth restriction

•oMultiple Pregnancy
•oPlatelet count < 50,000/mm3
•oPlasma creatinine value >= 2mg/dl
•oComatose patients
•oDeranged coagulation profile
•oKnown case of myasthenia gravis
•oKnown case of seizure disorder
•oPatients with Eclampsia (defined as presence of new-onset grand mal seizures in a woman with preeclampsia).
•oHypersensitivity to Magnesium.
•oWomen who have received have received magnesium sulphate therapy before being referred.

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