Multi-Institutional Registry for Malignant Peripheral Nerve Sheath Tumors

Washington University School of Medicine13 个研究点分布在 5 个国家目标入组 1,050 人开始时间: 2017年4月28日最近更新: 2026年3月9日

适应症

试验速览

阶段: 不适用
状态: 招募中
发起方: Washington University School of Medicine
入组人数: 1,050
试验地点: 13
主要终点: Radiographic characteristics of malignant peripheral nerve sheath tumor (MPNST)

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

First, the investigators plan to use a retrospective analysis to determine the clinical landscape of neurofibromatosis (NF)1-associated malignant peripheral nerve sheath tumor (MPNST) and precursor lesions (e.g., atypical or nodular plexiform neurofibromas). A worldwide database will be established, collecting, in a standardized manner, histologic, immunohistochemical, molecular, radiographic, treatment, and related clinical data from centers worldwide with expertise in these NF1-related cancers. Although retrospective in nature, the resulting data from this registry may reveal previously unanticipated patterns, similar to the INFACT effort outcome. This registry would then allow the acquisition of data associated with MPNST biospecimens collected under associated banks (frozen or paraffin-embedded, germline (or normal tissue DNA) samples, and any previously somatic whole-exome or whole-genome sequencing data for aggregate analyses). Second, the investigators plan to co-register patients to institutional banks in order to prospectively collect MPNST samples for analysis. These patients will be consented in order to collect the above information and for banking of tumor tissue and future studies that include genomic characterization of the tumors.

研究设计

研究类型: Observational
观察模型: Cohort
时间视角: Other

入排标准

性别: All
接受健康志愿者: 否

入选标准

未提供

排除标准

•Any patient diagnosed with an MPNST is eligible for enrollment to this registry provided s/he consents to participate (or consent form his/her parent or legal guardian or legally authorized representative is obtained).