Multi-Institutional Registry for Malignant Peripheral Nerve Sheath Tumors

Washington University School of Medicine13 个研究点分布在 5 个国家目标入组 1,050 人2017年4月28日

适应症Malignant Peripheral Nerve Sheath Tumors

概览

阶段: 不适用
干预措施: 未指定
疾病 / 适应症: Malignant Peripheral Nerve Sheath Tumors
发起方: Washington University School of Medicine
入组人数: 1050
试验地点: 13
主要终点: Radiographic characteristics of malignant peripheral nerve sheath tumor (MPNST)
状态: 招募中
最后更新: 上个月

概览研究者入排标准结局指标研究点相似试验

概览

简要总结

First, the investigators plan to use a retrospective analysis to determine the clinical landscape of neurofibromatosis (NF)1-associated malignant peripheral nerve sheath tumor (MPNST) and precursor lesions (e.g., atypical or nodular plexiform neurofibromas). A worldwide database will be established, collecting, in a standardized manner, histologic, immunohistochemical, molecular, radiographic, treatment, and related clinical data from centers worldwide with expertise in these NF1-related cancers. Although retrospective in nature, the resulting data from this registry may reveal previously unanticipated patterns, similar to the INFACT effort outcome. This registry would then allow the acquisition of data associated with MPNST biospecimens collected under associated banks (frozen or paraffin-embedded, germline (or normal tissue DNA) samples, and any previously somatic whole-exome or whole-genome sequencing data for aggregate analyses). Second, the investigators plan to co-register patients to institutional banks in order to prospectively collect MPNST samples for analysis. These patients will be consented in order to collect the above information and for banking of tumor tissue and future studies that include genomic characterization of the tumors.

注册库

clinicaltrials.gov

开始日期

2017年4月28日

结束日期

2053年4月30日

最后更新

上个月

研究类型

Observational

性别

All

研究者

发起方

Washington University School of Medicine

责任方

Sponsor

入排标准

入选标准

未提供

排除标准

•Any patient diagnosed with an MPNST is eligible for enrollment to this registry provided s/he consents to participate (or consent form his/her parent or legal guardian or legally authorized representative is obtained).