Effectiveness of morning versus evening dosing of antihypertensive medications with and without daily mobile reminders: a randomized controlled trial
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Mean reduction in systolic and diastolic blood pressure (measured in mmHg).
研究概览
简要总结
"MEANDER" is a prospective, randomized, open-label, controlled trial aiming to compare the effectiveness of morning versus evening dosing of antihypertensive medications on blood pressure control. The study also evaluates the role of WhatsApp medication reminders in improving adherence and assesses the combined effect of dosing time and reminders on patient satisfaction and blood pressure outcomes. Conducted over 8 weeks at Karnataka Medical College and Research Institute, Hubballi, this trial includes four groups with different combinations of dosing times and reminders, focusing on adults aged 18–65 with essential hypertension.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Adults aged 18–65 years with a diagnosis of essential hypertension.
- •On stable once-daily antihypertensive therapy for at least 4 weeks.
- •Access to a smartphone with WhatsApp installed.
- •Giving written consent for participating in the trial.
排除标准
- •Secondary hypertension or hypertensive emergencies.
- •Comorbid conditions requiring complex drug regimens.
- •Non-compliance or inability to adhere to the protocol.
结局指标
主要结局
Mean reduction in systolic and diastolic blood pressure (measured in mmHg).
时间窗: Baseline, 4 weeks, and 8 weeks.
次要结局
- Adherence to antihypertensive medication (measured using a validated scale like MMAS-8).(Baseline, 4 weeks, and 8 weeks.)
- Participant satisfaction with the intervention (measured using a satisfaction survey or questionnaire).(At the 8-week follow-up.)
- Incidence of adverse effects related to antihypertensive medications (e.g., dizziness, fatigue).(Monitored throughout the 8-week trial period.)
研究者
Dr Harshad Venugopal Ramineni
Karnataka Medical College and Research Institute, Hubballi