Metabolic and Immunological Phenotyping in Patients With Cancer
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Serum cortisol level
研究概览
简要总结
An observational study to investigate cachexia in participants with non-haematological cancer.
详细描述
A single-centre, non-randomised, observational study. This study will investigate the systemic metabolic and immunological changes that occur in cachexia. The aim is to better understand the mechanism(s) underlying weight loss in people with non-haematological cancer. This will help to facilitate future research to generate treatments to reverse weight loss and improve outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Have given written informed consent to participate
- •Be aged 18 years or over at the time of signing the informed consent form
- •Have a histological or cytological diagnosis of a non-haematological cancer
- •Are willing and able to comply with study procedures and visits
排除标准
- •Active infection, as determined by the investigator based on clinical symptoms and / or fever and / or requirement for antibiotics
- •Current treatment with chemotherapy, oral steroids or other immunosuppressive drugs (within 7 days of baseline investigations or during the study phase)
- •Significant acute, chronic or psychiatric condition or laboratory abnormality which in the judgment of the investigator would place the patient at undue risk or interfere with the study.
- •Intolerance to dairy products
- •Women, who are pregnant, plan to become pregnant or are lactating
结局指标
主要结局
Serum cortisol level
时间窗: Change from baseline serum cortisol level at Day 2
Blood serum cortisol levels in weight losing and weight stable patients at baseline and Day 2
次要结局
未报告次要终点
研究者
CCTU- Cancer Theme
Cambridge Clinical Trials Unit - Cancer Theme
Cambridge University Hospitals NHS Foundation Trust