The Effects of Anodal Stimulation on Left Ventricular Desynchrony and Hemodynamics in Patients With a Biventricular Pacemaker
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Myocardial Performance Index, dP/dT
研究概览
简要总结
To investigate the hemodynamic, inter and intraventricular desynchrony effects of anodal stimulation and triple site pacing compared with the usual dual site pacing by echocardiography and Tissue Doppler Imaging.
详细描述
Thirty patients who underwent CRT and had evidence of anodal stimulation will be included in the study. All patients undergo a conventional echocardiography after 10 minutes of continuous triple site pacing and after 10 minutes of continuous dual site pacing (Customary biventricular pacing).Echocardiography studies will be performed to measure dP/dT using continuous flow Doppler velocity profiles of mitral regurgitation, LV volumes and Left ventricular ejection fraction. Left intraventricular desynchrony is assessed by using TDI.
研究设计
- 研究类型
- Interventional
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with biventricular pacemakers who met currently accepted indications for CRT, including dilated cardiomyopathy with LV ejection fraction < 35% (ischemic and nonischemic etiologies) with New York Heart Association class III to IV congestive heart failure and QRS duration > 120 ms.
排除标准
- •Patients with first generation CRT device
- •Integrated bipolar defibrillator device
- •Atrial fibrillation during the screening phase
- •Patients who cannot tolerate triple site pacing for several minutes (i.e diaphragmatic pacing)
- •Patients with epicardial LV leads
- •Patients with LV leads located out of the lateral or posterolateral areas
结局指标
主要结局
Myocardial Performance Index, dP/dT
时间窗: After 10 minutes of triple site pacing and 10 minutes of dual sute pacing
次要结局
- Inter and intraventricular dyssynchrony parameters, LV volumes, LVEF(After 10 minutes of triple site pacing and 10 minutes of dual site pacing)