Generation of induced pluripotent stem cells from somatic cells of healthy individuals and patients with inherited heart diseases
- Conditions
- inherited cardiomyopathiesinherited heart rhythm disturbances healthy probandsI42I45CardiomyopathyOther conduction disorders
- Registration Number
- DRKS00009433
- Lead Sponsor
- Zentrum für Physiologie und Pathophysiologie,Institut für Neurophysiologie, Medizinische FakultätUniklinik KölnTel.: (0221) 478-86686Fax: (0221) 478-3834E-mail: tomo.saric@uni-koeln.de
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 41
Inclusion Criteria
for patients: signed consent form, dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, inborn arrhythmias (CPVT, LQTS, Brugada syndrome), legal capacity.
- for healthy tissue donors: signed consent form, no known acute or chronic diseases, legal capacity
Exclusion Criteria
infectious diseases (HIV, HCV, HBV), disseminated skin diseases or infections, urogenital infections, allergies against local anesthetics (e.g. Lidocain), blood clotting disturbances in test persons without heart diseases, persons in employment contract with the sponsor of the study, involuntary commitment into the mental hospital due to official or judicial order.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Isolation of cells from a skin biopsy, peripheral blood or urine
- Secondary Outcome Measures
Name Time Method Successful generation of induced pluripotent stem cells (iPS cells) from somatic cells of healthy individuals or patients with inherited heart diseases