Implicit Learning, Comorbidity and Stress Vulnerability in Chronic Functional Pain Syndromes
试验速览
- 阶段
- 不适用
- 入组人数
- 64
- 试验地点
- 2
研究概览
简要总结
The project investigates on the role of pain avoidance, comorbidity and stress response for the development of chronic somatic and visceral pain. We, the researchers at University Hospital Mannheim, assume that implicit operant learning of pain sensitization is a central mechanism of the process of pain becoming chronic, which is augmented by fear and by avoidance behaviour. Somatic and psychological comorbidity as well as stress factors are further promoting factors in chronic pain development.
详细描述
Study 1: Implicit operant learning of sensitization and habituation in an experimental heat pain model will be investigated and compared in healthy controls, chronic pain patients with fibromyalgia, with and w/o visceral pain.
Study 2: Functional imaging of implicit operant learning of sensitization and habituation in an experimental heat pain model (same subgroups as in study 1).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Fibromyalgia according to American College of Rheumatology (ACR) criteria
- •Visceral hypersensitivity according to ROME criteria
- •Chronic pain according to International Association for the Study of Pain (IASP) criteria
排除标准
- •Abnormal quantitative sensory testing
- •Psychiatric or neurological anamnesis, except fear and depression
- •Acute major depression
- •Substance abuse