Double ovarian stimulation (Shanghai and Duostim protocol)

Phase 3

• Conditions: Poor ovarian response.; Complications of attempted introduction of fertilized ovum following in vitro fertilization; N98.2

• Registration Number: IRCT20080831001141N35
• Lead Sponsor: Royan Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 27 May 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

Age =35 years
Antimullerian hormone (AMH) <1.2 ng/ml and/or antral follicular count=5 follicles
=4 oocyte retrieved from previous ART cycle
18.5<BMI<30

Exclusion Criteria

Endometriosis (stage III and IV)
Myoma with a compression effect
Uterine anomalies (Unicorn, Didelphis,etc,….)
Male factor infertility with azoospermia, severe oligospermia and oligoasthenospermia, TESE/PESA

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MII (Metaphase II) oocyte numbers and quality. Timepoint: Immediately after oocyte puncture. Method of measurement: Embryologist report.

Secondary Outcome Measures

Name	Time	Method
Cleaved embryo numbers. Timepoint: 2-3 days after oocyte puncture and sperm insemination. Method of measurement: Embryologist report.;Blastocyst numbers. Timepoint: 5 days after oocyte puncture and sperm insemination. Method of measurement: Embryologist report.;Clinical pregnancy rate. Timepoint: 4-6 weeks after embryo transfer. Method of measurement: Vaginal ultrasound.;Fertilization rate. Timepoint: 2-5 days after sperm insemination. Method of measurement: Embryologist report.