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Simplified basic immunisation after transplantation of stem cells

Phase 1
Conditions
Patients undergoing stem cell transplantation loose their protection from basic vaccinations done during childhood and need to be immunised again to be protected from diphteria, tetanus, polio and haemophilus influenza. Improved protection against pertussis will also be studied.
Therapeutic area: Body processes [G] - Immune system processes [G12]
Registration Number
EUCTR2014-005077-36-SE
Lead Sponsor
Örebro Läns Landsting
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
ot Recruiting
Sex
All
Target Recruitment
50
Inclusion Criteria

• Patients who have undergone allogeneic or autologous stem cell transplantation
• Male or female > 18 years old
• Patients who have given written consent to participate in the study
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 40
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 10

Exclusion Criteria

• Pregnancy confirmed / suspected by the patient upon request.
• Allergy or hypersensitivity to any of the vaccine constituents.
• Ongoing acute illness (temperature >38 degrees celsius).
• Other immunosuppressive disease or ongoing immunosuppressive therapy for other disease than GVH.
• Recurrence of malignancy.
• Treatment with rituximab in the last 6 months.
• Alcohol abuse.
• Mental retardation
• If the investigator for any other reason determines that the patient is not suitable to be included.

Study & Design

Study Type
Interventional clinical trial of medicinal product
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Secondary Outcome Measures
NameTimeMethod
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