Advanced and titanium platelet rich fibrin for treating intrabony defects.

Phase 3

Not yet recruiting

• Conditions: systemically healthy volunteers

• Registration Number: CTRI/2020/12/029963
• Lead Sponsor: Dr Anjali Gaba

Brief Summary

Thepresent study has been designed as a prospective controlled clinical trial. Thestudy will include suitable number of patients referred for treatment ofchronic periodontitis to the Department of Periodontology, Institute of DentalSciences, Bareilly.

Allparticipants will be informed about the risks and benefits of the procedure andsigned informed consent were taken from them.

Clinicalparameters and radiographic parameters will be recorded at different points oftime i.e. at baseline, 3 months and 6 months.

After recording clinical parameters and administeringphase-1 therapy, the site will be decided by tossing the coin and treatedeither with A-PRF or T-PRF along with bone graftafter raising a full thicknessflap and debridement.

GroupA: Flap surgery with A- PRF + Hydroxyapatite and Tricalcium phosphate (TCP)

GroupB: Flap surgery with T- PRF+ Hydroxyapatite and Tricalcium phosphate (TCP)

TheA-PRF is made in a glass tube as per procedures by Kobayashi et al (2014).

TheT-PRF is made in a titanium test tube that is of medical grade titanium as perprocedures by Mustafa Tunali et al (2011).

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2020-12-19
• Study Start: 2020-12-21

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• Patients having minimum of 20 permanent teeth.
• Age group of 20 to 55 years.
• Probing pocket depth ≥ 5mm.
• Clinical attachment loss ≥3mm.
• Radiographic evidence of intrabony defect.

Exclusion Criteria

• Systemically compromised patients.
• Patients who are on medications that could interfere with wound healing.
• Patients with grade III mobility.
• Chronic smokers and alcoholics.
• Pregnant and lactating females.
• Patients who had undergone periodontal treatment with in a period of last 1 year.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
•To evaluate and compare clinical and radiographic outcome of Advanced Platelet - rich fibrin (A-PRF + bone graft) and Titanium Platelet-rich fibrin (T PRF + bone graft) in the treatment of intrabony defect resulting from periodontal disease.	6 months

Secondary Outcome Measures

Name	Time	Method
To evaluate the clinical and radiographic outcome after performing periodontal regenerative therapy with A-PRF	To evaluate the clinical and radiographic outcome after performing periodontal regenerative therapy with T-PRF

Trial Locations

Locations (1)

institiute of dental sciences; 🇮🇳 Bareilly, UTTAR PRADESH, India

institiute of dental sciences

🇮🇳Bareilly, UTTAR PRADESH, India

Dr Anjali Gaba

Principal investigator

8958683345

dranjaligaba4531@gmail.com