The Safety and Effectiveness of Zidovudine Plus Acyclovir in Patients With Early HIV Infection
- Conditions
- HIV Infections
- Registration Number
- NCT00002290
- Lead Sponsor
- Glaxo Wellcome
- Brief Summary
This double-blind, placebo-controlled study is designed to determine the long-term safety and efficacy of concurrent oral Retrovir / Zovirax (AZT and ACV) therapy and oral AZT therapy alone, in the treatment of early symptomatic HIV infection. Efficacy will be evaluated by monitoring the incidence, severity, and time of development of opportunistic infections and other manifestations of advanced symptomatic HIV infection. The effects of the combination and single AZT therapy on immune function and viral replication will also be evaluated. Study participants will be monitored for evidence of toxicity or intolerance to concurrent AZT / ACV administration and AZT therapy alone.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (14)
Birmingham Veterans Administration Med Ctr / Univ of Alabama
🇺🇸Birmingham, Alabama, United States
Univ of Arizona / Health Science Ctr
🇺🇸Tucson, Arizona, United States
ViRx Inc
🇺🇸San Francisco, California, United States
Georgetown Univ Med Ctr / Main Hosp 4
🇺🇸Washington, District of Columbia, United States
Veterans Administration Med Ctr
🇺🇸Bay Pines, Florida, United States
Rush Presbyterian - Saint Luke's Med Ctr
🇺🇸Chicago, Illinois, United States
Harper Hosp
🇺🇸Detroit, Michigan, United States
Univ of Pennsylvania / HIV Clinic
🇺🇸Philadelphia, Pennsylvania, United States
Vanderbilt School of Medicine
🇺🇸Nashville, Tennessee, United States
Univ TX Galveston Med Branch
🇺🇸Galveston, Texas, United States
Scroll for more (4 remaining)Birmingham Veterans Administration Med Ctr / Univ of Alabama🇺🇸Birmingham, Alabama, United States