NCT02550808Unknown不适用
Metabolic and Histological Changes in Skeletal Muscle and Fat Tissue in Patients With Chronic Cardiopulmonary Disease
General and Teaching Hospital Celje1 个研究点 分布在 1 个国家目标入组 400 人开始时间: 2012年3月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Insulin resistance (HOMA-IR)
研究概览
简要总结
This study aims to evaluate prevalence of sarcopenia and cachexia in patients with chronic cardiopulmonary disease. The investigators will also investigate metabolic disorders like glucose metabolism, presence of metabolic syndrome, body composition and histological changes in skeletal muscle and body fat. Finally, patients will be followed for clinical endpoints.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •diagnosis of chronic disease (Heart failure, COPD, malignancy, CKD) or no diagnosis (controls)
排除标准
- •refuse to participate
结局指标
主要结局
Insulin resistance (HOMA-IR)
时间窗: Baseline
HOMA-IR as calculated by formula using insulin and blood glucose
次要结局
- Muscle strength (Handgrip test)(Baseline)
- Change in apoptosis in skeletal muscle (number of apoptotic cells per square mm)(Baseline and after 5 weeks)
- Change in exercise capacity (6 minute walk test)(baseline and after 5 weeks)
- Neurohormonal activation (NT-proBNP concentration)(Baseline)
- Change in insulin resistance (HOMA-IR)(Baseline and after 5 weeks)
研究者
Mitja Lainscak
Professor of Internal Medicine
General and Teaching Hospital Celje
研究点 (1)
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