Cold-induced Thermogenesis in Adults From Siberia and Western Europe
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Cold-induced thermogenesis
研究概览
简要总结
Cold-induced thermogenesis, or the increase in energy expenditure upon cold exposure, indicates metabolic stress, as such, cold-induced thermogenesis may signal an appropriate stimulus to improve metabolic health. Cold acclimation may alter cold-induced thermogenesis due to changes in (non)shivering thermogenesis and blood flow. The main aim of this research is to compare the energy expenditure responses, during a standardised cold stress (~ 9°C air temperature, maximum 1 hour), of Siberian adults with Western European adults. The subjects will be individually matched for age, sex, body mass and height. It was hypothesised that cold-induced thermogenesis will be reduced in the Siberian population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Signed informed consent
- •Western European origin or of Siberian origin
- •BMI between 18.5 and 35 kg/m2
- •Generally healthy (determined by dependent physician)
排除标准
- •Active, uncontrolled cardiovascular disease or cancer
- •Raynaud's disease
- •Participation in another biomedical study within 1 month before the first study
- •Cold-acclimated (Western European group), such as takes daily extended cold baths, works in a refrigerated environment, or regular cold-water swimming within 1 month of starting the study
- •Medication use known to hamper subject's safety during study procedures
- •Abuse of alcohol or drugs
结局指标
主要结局
Cold-induced thermogenesis
时间窗: 30 min before and during the cold exposure (maximum 1 hour)
Energy expenditure with indirect calorimetry
次要结局
- Substrate oxidation(30 min before and during the cold exposure (maximum 1 hour))
- Skin temperature(30 min before and during the cold exposure (maximum 1 hour))
- Core temperature(30 min before and during the cold exposure (maximum 1 hour))
- Shivering activity(30 min before and during the cold exposure (maximum 1 hour))