The efficacy of combination therapy of clomiphen citrate and pioglithazone in induction ovulation and pregnancy
- Conditions
- Poly cystic Ovary Syndrome.Polycystic Ovarian Syndrome
- Registration Number
- IRCT2013071013932N1
- Lead Sponsor
- Hormozgan University of Medical Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 49
Patients with history of anovulatory cycles during the past two months in addition to one of the following conditions:Serum progestrone level less than 5 mg during the mid-luteal phase; Hirsutism; Positive response to medroxy-progesterone acetate withdrawal test; Serum testosterone level higher than 65 Ng/Dl
Exclusion criteria; patients with confirmed diabetes mellitus or fasting blood glucose higher than 125 mg/dl; congenital adrenal hyperplasia which was confirmed by 17-alpha hydroxy progesterone level of 200 ng/dl or higher; patients with underlying disorders such as thyroid disease; hyperprolactinemia; congenital heart disease; hypertension; renal and liver dysfunction; patients who had received any hypoglycemic agent or inducing ovulation medications during 30days ago.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ovulation. Timepoint: one month after intervention. Method of measurement: vaginal bleeding.
- Secondary Outcome Measures
Name Time Method Pregnancy. Timepoint: 2 month after intervention. Method of measurement: beta human chorionic gonadotropine of serum.