Effect of Prebiotics on Intestinal Gas Production, Microbiota and Digestive Symptoms
- Conditions
- Healthy
- Interventions
- Dietary Supplement: Bimuno Galacto-oligo-saccharide
- Registration Number
- NCT02618239
- Brief Summary
Non-absorbable, fermentable residues in the diet increase intestinal gas production and induce gas-related symptoms, such as flatulence, abdominal bloating and distention; however, prebiotics, which are also fermented by colonic bacteria have been shown to improve this type of symptoms. The aim is to demonstrate changes in metabolic activity of gut microbiota and colonic biomass induced by prebiotics.
Healthy subjects (n=20) will be administered a prebiotic (Galacto-oligo-saccharide; 2.8 g/d) for 3 weeks; they will also receive a standard diet during three days. The following outcomes will be measured immediately before, at the beginning and at the end of the treatment: a) number of gas evacuations during daytime for 2 days on the standard diet, by means of an event marker; b) volume of gas evacuated via a rectal tube during 4 hours after a test meal, by means of a barostat; c) microbiota composition by fecal analysis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
- gastrointestinal symptoms
- recent (3 months) antibiotic intake
- recent (3 months) change of diet
- recent (3 months) gastroenteritis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Healthy subjects Bimuno Galacto-oligo-saccharide Bimuno Galacto-oligo-saccharide administration 2.7 g/d x 3 weeks
- Primary Outcome Measures
Name Time Method Number of daily anal gas evacuations Change from beginning of treatment (mean of days 2 and 3) to end of treatment (mean of days 20 and 21)
- Secondary Outcome Measures
Name Time Method Volume of anal gas evacuation Change from beginning of treatment (day 3) to end of treatment (day 21)