Frailty, Hip Fractures and Inflammatory Biomarkers

Recruiting

• Conditions: Frailty; Hip Fracture; Inflammatory Biomarkers

• Registration Number: NCT06614478
• Lead Sponsor: University of Thessaly

Brief Summary

We ought to investigate if hip fracture patients suffering from frailty have higher inflammatory burden according to simple inflammatory biomarkers.

Detailed Description

Frailty (F) is a prevalent syndrome among elderly patient with hip fractures (HF) and has been linked to poor prognosis. Inflammatory biomarkers have been used as prognostic indexes in patients with HF. We ought to investigate if hip fracture patients suffering from frailty have higher inflammatory burden according to simple inflammatory biomarkers.

Study Timeline

• Study Start: 2023-04-01
• Status Verified: 2024-09
• Study First Submitted: 2024-09-23
• Study First Submitted QC: 2024-09-23
• Last Update Submitted: 2024-09-23
• Study First Posted: 2024-09-26
• Last Update Posted: 2024-09-26
• Primary Completion: 2025-12-31
• Study Completion: 2026-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• age >65 years, ASA PS I-III, non- institutionalized, able to communicate patients

Exclusion Criteria

• Patients with severe cognitive dysfunction, those treated conservatively, those with pathological fractures and patients who refused to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Frailty status	preoperatively	Frailty will be categorized based on the validated Groningen Frailty Indicator (GFI) as non-frail (NF, score 0,1), pre-frail (PF, score 2, 3) and severe frail (SF, score \>4).
Inflammatory biomarkers	preoperatively	Upon admission and immediate before surgery upper limits of white blood cells (WBC) within normal range (WBC \>8 10\^3/μL), NLR (neutrophils/lymphocytes), PLR (platelets/lymphocytes), CRP (C-reactive protein) and CLR (CRP/lymphocytes), will be recorded.

Trial Locations

Locations (2)

Larissa University Hospital; 🇬🇷 Larissa, Thessaly, Greece

UHL; 🇬🇷 Larissa, Thessaly, Greece