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Clinical Trials/NCT03862716
NCT03862716CompletedPhase 3

Remission Evaluation of a Metabolic Intervention for Type 2 Diabetes With IDegLira (REMIT IDegLira): A Randomized Controlled Trial

Population Health Research Institute8 sites in 1 country159 target enrollmentStarted: April 23, 2019Last updated:
Conditions
Interventions
Drugs

Trial Snapshot

Phase
Phase 3
Status
Completed
Enrollment
159
Locations
8
Primary Endpoint
Proportion of participants achieving drug-free diabetes remission

Study Overview

Brief Summary

The purpose of the study is to determine whether in patients with early type 2 diabetes, a short-term intensive metabolic intervention comprising IDegLira, metformin, and lifestyle approaches will be superior to standard diabetes therapy in achieving sustained diabetes remission.

Detailed Description

This is a multicentre, open-label, randomized controlled trial in 160 patients with recently-diagnosed T2DM. Participants will be randomized to 2 treatment groups: (a) a 16-week course of treatment with IDegLira, metformin and lifestyle therapy, and (b) standard diabetes therapy, and followed for a total of 68 weeks (1 year and 4 months). In all participants with HbA1C<7.3% at the 16 week visit, glucose-lowering medications will be discontinued and participants will be encouraged to continue with lifestyle modifications and regular glucose monitoring. Participants with HbA1C ≥ 7.3% at this visit or who experience hyperglycemia relapse after stopping drugs will receive standard glycemic management as informed by the current Canadian Diabetes Association clinical practice guidelines.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Treatment
Masking
None

Eligibility Criteria

Ages
30 Years to 80 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • men and women aged 30-80 years;
  • T2D diagnosed within 5 years
  • stable T2D drug regimen in the 8 weeks before randomization;
  • HbA1c 6.5-9.5% on no glucose lowering drugs, or 6.5%-8.0% on up to 2 glucose lowering drugs;
  • body mass index ≥ 23 kg/m2;
  • ability and willingness to perform self-monitoring of capillary blood glucose (SMBG);
  • willingness to wear a continuous glucose monitor on at least 3 occasions;
  • ability and willingness to self-inject IDegLira and insulin;
  • provision of informed consent.

Exclusion Criteria

  • current use of insulin therapy;
  • history of hypoglycemia unawareness, or severe hypoglycemia requiring assistance;
  • history of end-stage renal disease or eGFR<45 mL/min/1.73 m2 by MDRD formula;
  • active liver disease or elevated alanine transferase (ALT) levels ≥ 2.5 times the upper limit of normal at the time of enrolment;
  • history or clinical suspicion of pancreatitis or medullary thyroid cancer;
  • diagnosis or first degree relative with Multiple Endocrine Neoplasia Type 2 (MEN2);
  • history of diabetic retinopathy requiring photocoagulation, injection therapy or vitrectomy;
  • history of cardiovascular disease (unless cleared for a moderate intensity exercise program by a specialist) including: i. acute coronary syndrome, hospitalization for unstable angina, myocardial infarction, or revascularization with coronary artery bypass grafting or percutaneous coronary intervention; ii. peripheral vascular disease, valvular heart disease, cardiomyopathy, aortic dissection, tachyarrhythmias, bradyarrhythmias, prior stroke or TIA; iii. prior hospitalization for heart failure; or iv. ECG findings concerning for ischemic heart disease (i.e. pathological Q-waves, ST-segment-T-wave abnormalities in contiguous leads, left anterior hemiblock, left bundle branch block, second or third degree atrioventricular block).
  • history of any disease requiring frequent intermittent or continuous systemic glucocorticoid treatment;
  • history of bariatric surgery, or planned bariatric surgery in the next 1.5 years;
  • history of any major illness with a life expectancy of < 3 years;
  • history of injury or any other condition that significantly limits participant's ability to achieve moderate levels of physical activity;
  • excessive alcohol intake, acute or chronic;
  • currently pregnant, or breastfeeding, or not using a reliable method of birth control for the duration of the trial in all females with childbearing potential;
  • inability to take insulin degludec, liraglutide or metformin.

Arms & Interventions

Intervention

Experimental

Drug: IDegLira - sc injection; Drug: metformin - oral administration; Drug: insulin degludec - sc injection; Behavioral: lifestyle therapy, diet and exercise

Intervention: IDegLira (Drug)

Intervention

Experimental

Drug: IDegLira - sc injection; Drug: metformin - oral administration; Drug: insulin degludec - sc injection; Behavioral: lifestyle therapy, diet and exercise

Intervention: insulin degludec (Drug)

Intervention

Experimental

Drug: IDegLira - sc injection; Drug: metformin - oral administration; Drug: insulin degludec - sc injection; Behavioral: lifestyle therapy, diet and exercise

Intervention: Metformin (Drug)

Intervention

Experimental

Drug: IDegLira - sc injection; Drug: metformin - oral administration; Drug: insulin degludec - sc injection; Behavioral: lifestyle therapy, diet and exercise

Intervention: Lifestyle Therapy (Behavioral)

Outcomes

Primary Outcomes

Proportion of participants achieving drug-free diabetes remission

Time Frame: 28 weeks after randomization

Drug-free diabetes remission is defined as HbA1C \< 6.5 % off glucose-lowering agents for at least 12 weeks.

Secondary Outcomes

  • Proportion of participants achieving drug-free diabetes remission(28 weeks, 40 weeks, 52 weeks and 68 weeks after randomization)
  • Proportion of participants achieving drug-free normoglycemia(28 weeks, 40 weeks, 52 weeks and 68 weeks after randomization)
  • Proportion of participants achieving drug-free diabetes regression(28 weeks, 40 weeks, 52 weeks and 68 weeks after randomization)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (8)

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