Efficacy of low-dose naloxone for the prevention of acute remifentanil-induced hyperalgesia

Phase 3

Conditions: Hyperalgesia.

Registration Number: IRCT20101122005225N8

Lead Sponsor: Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Female

Target Recruitment: 75

Inclusion Criteria

Female patients aged between 18 to 75 years
ASA (American Society of Anesthesiologists) I-II patients
Patients scheduled for elective hysterectomy

Exclusion Criteria

Uncontrolled diabetes mellitus
Neurologic disorders
Psychologic disorders which needs treatment
Inflammatory and renal diseases
Drug abuse
Routine use or taking NSAIDs, opioids or other analgesics 48 hours prior to surgery
Allergy or contraindication to anesthetic agents or pain medications, including NSAID’s, acetaminophen and opioids
History of any type of chronic pain needs medical or interventional treatments
Patient who develop any surgical or anesthetic complication, or need reoperation
Patients receiving ketamine, antipsychotic or gabapentinoids

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To decrease post operative hyperalgesia assessed by static tactile tests. The severity of pain in a static tactile test was reported as VAS. Timepoint: 0.5, 2, 6, 12, and 24 hours after surgery. Method of measurement: Static tactile test using a fine brush.

Secondary Outcome Measures

Name	Time	Method
Total morphin dose used in post operative period. Timepoint: During the 24 hour period after surgery. Method of measurement: Reported in Mg showed by analgesia pump.;The time of first rescue dose of morphine in post operative period. Timepoint: In post operative period. Method of measurement: It is reported as the time interval to the end of surgery.