Primary Prevention of Major Adverse Cardiac Events (MACE) With Standard and Intensive Statin Treatment in Patients With Diabetes: Survival and Cardiovascular Event Assessments
- Conditions
- HypercholesterolemiaType 2 DiabetesHypertension
- Interventions
- Registration Number
- NCT01173939
- Lead Sponsor
- Positive Trial Group
- Brief Summary
The study is being conducted to compare the effect of standard treatment (target LDL-C level: \<120 mg/dL (JASGL 2007 target level)) and intensive treatment (target LDL-C level: \<70 mg/dL) in the prevention of major adverse cardiac events (MACE) in hypercholesterolemia patients with concomitant type 2 diabetes and hypertension.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 10000
Patients meeting the following inclusion criteria will be included in the study:
-
Patients giving voluntary written consent to participate in the study
-
Male or female patients 50 years of age or older (at informed consent)
-
Hypercholesterolemia patients (Untreated patients: LDL-C level ≥140 mg/dL; treated patients: LDL-C level ≥120 mg/dL)
-
Type 2 diabetes patients (HbA1c level ≥6.1% (JDS criteria), with or without history of drug therapy)
-
Hypertension patients (SBP ≥130 mmHg or DBP ≥80 mmHg, with or without history of drug therapy)
-
Patients with two or more of the following risk factors
- Male
- 65 years of age or older
- Smoker
- L/H ratio: ≥3.0 •HbA1c level: ≥8.0%
- Left ventricular hypertrophy
- First- or second-degree family history of MACE
- Microalbuminuria (quantitative testing: ≥30 mg/dL), proteinuria (qualitative testing: + or higher) or eGFR (<60 mL/min/1.73 m2)
Patients meeting the following criteria will be excluded from the study:
- Patients receiving rosuvastatin, pitavastatin, or atorvastatin therapy within one month prior to informed consent
- Patients judged to have familial hypercholesterolemia
- Patients with a serum triglyceride level of ≥400 mg/dL
- Patients with a history of myocardial infarction
- Patients with a history of coronary revascularization (PCI or CABG)
- Patients with a history of treatment of unstable angina
- Patients with a history of cerebrovascular accident (excluding asymptomatic lacunar infarction)
- Heart failure patients
- Patients with a history of hypersensitivity to statins
- Patients with a history of drug-induced myopathy
- Patients with poorly controlled arrhythmia
- Patients with severe liver or kidney disease
- Patients with serious concurrent disease, such as malignancy, or patients with severely limited lifespan
- Patients who are or may be pregnant
- Patients judged by the investigators to be ineligible for participation in the study for any other reason
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Intensive Rosuvastatin Group Rosuvastatin - Active comparator: Standard Pravastatin Group Pravastatin -
- Primary Outcome Measures
Name Time Method MACE (time to event): MACE (time to event): myocardial infarction, unstable angina, cardiovascular death, revascularization, fatal/nonfatal cerebrovascular accident, peripheral arteriopathy, aortic event At the end of the study or discontinuation up to 4 years
- Secondary Outcome Measures
Name Time Method Prevention of individual MACE At the end of the study (or discontinuation) Prevention of MACE(combination of each category) At the end of the study (or discontinuation) Prevention, frequency and distribution of type of the following non-MACE cardiac and cerebrovascular events during the study period: heart failure requiring hospitalization, transient ischemic attack (TIA), abnormal ankle-brachial index (abnormal ABI) At study completion up to 4 years Frequency and distribution of type of MACE during the study period Including correlation with LDL-C, HDL-C and LDL-C/HDL-C ratio (hereafter referred to as "L/H ratio") At the end of the study or discontinuation up to 4 years Frequency and distribution of type of deaths during the study period At the end of the study or discontinuation up to 4 years Frequency and distribution of type of hospitalizations during the study period At the end of the study or discontinuation up to 4 years Frequency of other events (malignancy, dementia, need of nursing care) At the end of the study or discontinuation up to 4 years Frequency and type of adverse events At the end of the study or discontinuation up to 4 years
Trial Locations
- Locations (309)
Seiwadai Clinic
🇯🇵Kitakatsuragi gun, Nara pref., Japan
Sato Clinic
🇯🇵Suzaka city, Nagano pref., Japan
Abies Clinic
🇯🇵Fukuoka city, Fukuoka pref., Japan
Hiramitsu Heart Clinic
🇯🇵Nagoya city, Aichi pref., Japan
Tsugawa Internal Medicine Clinic
🇯🇵Echizen city, Fukui pref., Japan
Imura Internal Medicine Clinic
🇯🇵Hakusan city, Ishikawa pref., Japan
Katsura General Clinic
🇯🇵Morioka city, Iwate pref., Japan
Hakuai Iin
🇯🇵Sagamihara city, Kanagawa pref., Japan
Kasuya Clinic
🇯🇵Atsugi City, Kanagawa pref., Japan
Kuboshima Clinic
🇯🇵Fujisawa city, Kanagawa pref., Japan
Seisuikai Yoshioka QQ Clinic
🇯🇵Kurokawa gun, Miyagi pref., Japan
Obayashi Clinic
🇯🇵Sumida city, Tokyo, Japan
Shiraishi Iin
🇯🇵Edogawa ku, Tokyo, Japan
Okubo Clinic
🇯🇵Akishima city, Tokyo, Japan
Koshino Clinic
🇯🇵Sakai city, Fukui pref., Japan
Fukuoka Tokushukai Medical Center
🇯🇵Kasuga city, Fukuoka pref., Japan
Morizono Naika
🇯🇵Kitakyusyu city, Fukuoka pref., Japan
Miyazawa Cardiovascular And Internal Medicine Clinic
🇯🇵Kato-gun, Hokkaido pref., Japan
Jiyugaoka Yamada Clinic
🇯🇵Obihiro city, Hokkaido pref., Japan
Hiro Clinic
🇯🇵Sapporo city, Hokkaido pref., Japan
Seiwa Memorial Hospital
🇯🇵Sapporo city, Hokkaido pref., Japan
Kotani Diabetes Clinic
🇯🇵Kobe city, Hyogo pref, Japan
Arai Naika Clinic
🇯🇵Kanazawa city, Ishikawa pref., Japan
Morita Hospital
🇯🇵Komatsu city, Ishikawa pref., Japan
Hayashi Clinic
🇯🇵Marugame city, Kagawa pref., Japan
Kokuho Central Hospital
🇯🇵Shiki gun, Nara pref., Japan
Kawaguchi Clinic
🇯🇵Nagaoka city, Niigata pref., Japan
Sumi Cardiology Clinic
🇯🇵Oita city, Oiat pref., Japan
Tsuzaki Clinic
🇯🇵Oita city, Oiat pref., Japan
Inada Clinic
🇯🇵Kurashiki city, Okayama pref., Japan
Hisamatsu Medical Clinic
🇯🇵Okayama city, Okayama pref., Japan
Taisei Clinic
🇯🇵Hirakata city, Osaka pref., Japan
Kanazawa Clinic
🇯🇵Izumi city, Osaka pref., Japan
Mori Iin
🇯🇵Kishiwada city, Osaka pref., Japan
Kondo Clinic
🇯🇵Osaka city, Osaka pref., Japan
Ueda Clinic
🇯🇵Osaka city, Osaka pref., Japan
Ohta Iin
🇯🇵Sakai city, Osaka pref., Japan
Ban Clinic
🇯🇵Suita city, Osaka pref., Japan
Kobayashi Clinic
🇯🇵Suita city, Osaka pref., Japan
Yada Clinic
🇯🇵Takaishi city, Osaka pref., Japan
Matsumoto Clinic
🇯🇵Koshigaya city, Saitama pref., Japan
Akimoto Clinic
🇯🇵Saitama city, Saitama pref., Japan
Suzuhiro Clinic
🇯🇵Saitama city, Saitama pref., Japan
Akiyama Clinic
🇯🇵Shizuoka city, Shizuoka pref., Japan
Ueno Clinic
🇯🇵Yaizu city, Shizuoka pref., Japan
Takahashi Medical Clinic
🇯🇵Ohtawara city, Tochigi pref., Japan
Murakami Clinic
🇯🇵Anan city, Tokushima pref., Japan
Ueta Clinic
🇯🇵Myozai gun, Tokushima pref., Japan
Kensei Uchimachi Clinic
🇯🇵Tokushima city, Tokushima pref., Japan
Takayama Iin
🇯🇵Mitaka-shi, Tokyo, Japan
Ehime Medical CO-OP Izumigawa Clinic
🇯🇵Niihama city, Ehime pref., Japan
Matsuno Medical Clinic
🇯🇵Iyo gun, Ehime pref., Japan
Dr. Kodama's Office of Internal Medicine
🇯🇵Nishinomiya city, Hyogo pref, Japan
Kikuchi Clinic
🇯🇵Yokohama city, Kanagawa pref., Japan
Hirayasu Iin
🇯🇵Kawasaki city, Kanagawa pref., Japan
International Goodwill Hospital
🇯🇵Yokohama city, Kanagawa pref., Japan
Fukushi Clinic
🇯🇵Aomori city, Japan
Shimokurata Heart Clinic
🇯🇵Yokohama city, Kanagawa pref., Japan
Ootsuka Hospital
🇯🇵Kumamoto city, Kumamoto pref., Japan
Suefuji Naika Junkankika
🇯🇵Kumamoto city, Kumamoto pref., Japan
Doi Cardiovascular Clinic
🇯🇵Kumamoto city, Kumamoto pref., Japan
Kiyota Junkanki Naika Iin
🇯🇵Kumamoto city, Kumamoto pref., Japan
Haraguchi Circular&Internal Medical Clinic
🇯🇵Kumamoto city, Kumamoto pref., Japan
Maki Cardiovascular Clinic
🇯🇵Kumamoto city, Kumamoto pref., Japan
Terao Hospital
🇯🇵Kumamoto city, Kumamoto pref., Japan
Munakata Clinic
🇯🇵Shimomashiki gun, Kumamoto pref., Japan
Yamoto-naika Clinic
🇯🇵Higashi matsushima city, Miyagi pref., Japan
Shinagawa Clinic
🇯🇵Nagasaki city, Nagasaki pref., Japan
Ohtomo Clinic
🇯🇵Tome City, Miyagi pref., Japan
Yokoyama Medical Clinic
🇯🇵Shiojiri city, Nagano pref., Japan
Takanohara Suzuran-naika
🇯🇵Nara city, Nara pref., Japan
Ninomiya Clinic
🇯🇵Oita city, Oiat pref., Japan
Misugi Clinic
🇯🇵Kaizuka city, Osaka pref., Japan
Eguchi Clinic
🇯🇵Shizuoka city, Shizuoka pref., Japan
Masuda Naika
🇯🇵Utsunomiya city, Tochigi pref., Japan
Kimura Internal Medicine Clinic
🇯🇵Yoshinokawa city, Tokushima pref., Japan
Limbs Tokushima Clinic
🇯🇵Tokushima city, Tokushima pref., Japan
Sugawara Clinic
🇯🇵Nerima ku, Tokyo, Japan
Okuyama Clinic
🇯🇵Obanazawa city, Yamagata pref., Japan
Sakae Clinic
🇯🇵Obanazawa city, Yamagata pref., Japan
Isoda Clinic
🇯🇵Yamagata city, Yamagata pref., Japan
Noda Clinic
🇯🇵Shimonoseki city, Yamaguchi pref., Japan
Johno Clinic
🇯🇵Shimonoseki city, Yamaguchi pref., Japan
Shimasaki Clinic
🇯🇵Yamagata city, Yamagata pref., Japan
Iwasaki Naika Iin
🇯🇵Iwakuni city, Yamaguchi pref., Japan
Matsuda Medical Clinic
🇯🇵Shimonoseki city, Yamaguchi pref., Japan
Ayame Medical Clinic
🇯🇵Shimonoseki city, Yamaguchi pref., Japan
Shakaiiryouhoujin Onaka Hospital
🇯🇵Ube City, Yamaguchi pref., Japan
Mizumachi Medical Clinic
🇯🇵Shimonoseki city, Yamaguchi pref., Japan
Watada-naika Hospital
🇯🇵Ube city, Yamaguchi pref., Japan
Yoshizaki Clinic
🇯🇵Chuo city, Yamanashi pref., Japan
Fujii Clinic
🇯🇵Ube City, Yamaguchi pref., Japan
Ouchi Clinic
🇯🇵Yamaguchi city, Yamaguchi pref., Japan
Kashiwagi Clinic
🇯🇵Ayase city, Japan
Hayashi Diabetes Clinic
🇯🇵Chigasaki city, Japan
Nitta Medical Clinic
🇯🇵Kamiinagun, Japan
Uchiyama Clinic
🇯🇵Joetsu city, Japan
Imai Clinic
🇯🇵Kawasaki city, Japan
Tani Clinic
🇯🇵Kitakyusyu City, Japan
Marumo Clinic
🇯🇵Koganei city, Japan
Goko-Hospital
🇯🇵Matsudo city, Japan
Satou Clinic
🇯🇵Moka city, Japan
Ihara Clinic
🇯🇵Kyoto city, Japan
Iino Clinic
🇯🇵Nirasaki city, Japan
Miura Clinic
🇯🇵Osaka City, Japan
Kumagai Clinic
🇯🇵Shinshiro city, Japan
Kuroda Iin
🇯🇵Otsuki City, Japan
Sasaki Clinic
🇯🇵Sendai city, Japan
Satou Iin
🇯🇵Shimoinagun, Japan
Nishikawa Clinic
🇯🇵Shimoda city, Japan
Jiyukai Yamada Naika
🇯🇵Yokohama city, Japan
Kamata Clinic of Internal Medicine
🇯🇵Shiki city, Japan
Benibana Clinic
🇯🇵Yamagata city, Japan
Shonan Ochanomizu Clinic
🇯🇵Yokohama city, Japan
Suzuki Clinic
🇯🇵Toyokawa city, Japan
Hongo Clinic
🇯🇵Yokohama city, Japan
Fujimi Clinic
🇯🇵Yokohama city, Japan
Tani Clinic Internal Medicine, Allergology & Rheumatology
🇯🇵Yokohama city, Japan
Fukuoka University Chikushi Hospital
🇯🇵Chikushino city, Fukuoka pref., Japan
Saiseikai Futsukaichi Hospital
🇯🇵Chikushino city, Fukuoka pref., Japan
Hirano Medical Clinic
🇯🇵Fukuoka city, Fukuoka pref., Japan
Saku Hospital
🇯🇵Fukuoka city, Fukuoka pref., Japan
Fukui Chuo Clinic
🇯🇵Fukui city, Fukui pref., Japan
Kyoaikai Hospital
🇯🇵Hakodate city, Hokkaido pref., Japan
Medical Dock&Clinic
🇯🇵Nagoya city, Aichi pref., Japan
Ishite Matsumoto Naika Junkanki Clinic
🇯🇵Matsuyama city, Ehime pref., Japan
Kawai Naika Clinic
🇯🇵Gifu city, Gifu pref., Japan
Medical and Radiology Clinic Caress Sapporo Hokko Memorial Hospital
🇯🇵Sapporo city, Hokkaido pref., Japan
Koga Hospital
🇯🇵Koga city, Ibaraki pref., Japan
Koni Clinic
🇯🇵Kahoku gun, Ishikawa pref., Japan
Kondo Clinic Mamigaoka Purified Center
🇯🇵Kitakatsuragi gun, Nara pref., Japan
Naitoh Clinic
🇯🇵Fukuoka city, Fukuoka pref., Japan
Hijirigaoka Hospital
🇯🇵Date city, Hokkaido pref., Japan
Yanagi Medical Clinic
🇯🇵Hakusan city, Ishikawa pref., Japan
Hananomiya Clinic
🇯🇵Takamatsu city, Kagawa pref., Japan
Hasegawa Outpatients Clinic for Cardiovascular Disease
🇯🇵Takamatsu city, Kagawa pref., Japan
Kojima Clinic
🇯🇵Odawara city, Kanagawa pref., Japan
Takahashi Clinic
🇯🇵Nishi Yatsushiro gun, Yamanashi pref., Japan
Shohei Clinic
🇯🇵Kamakura city, Kanagawa pref., Japan
Kamegaya Medical Clinic
🇯🇵Kawasaki city, Kanagawa pref., Japan
Kirimura Iin
🇯🇵Kawasaki city, Kanagawa pref., Japan
Sakanashi Heart Clinic
🇯🇵Aso city, Kumamoto pref., Japan
Kawaguchi Hospital
🇯🇵Kikuchi city, Kumamoto pref., Japan
Jinnouchi Clinic Diabetes Care Center
🇯🇵Kumamoto city, Kumamoto pref., Japan
Nozuhara Clinic
🇯🇵Kumamoto city, Kumamoto pref., Japan
Isoda Internal Medical Clinic
🇯🇵Kyoto city, Kyoto pref., Japan
Omoto Clinic
🇯🇵Kyoto city, Kyoto pref., Japan
Kimura Naika Clinic
🇯🇵Yosa gun, Kyoto pref., Japan
Uyama Naika Clinic
🇯🇵Ikoma city, Nara pref., Japan
Clinic Jinguumae
🇯🇵Kahihara city, Nara pref., Japan
Doi Clinic
🇯🇵Kashihara city, Nara pref., Japan
Miyamoto Clinic
🇯🇵Kashihara city, Nara pref., Japan
Hiroshima General Hospital of West Japan Railway Company
🇯🇵Hiroshima city, Hiroshima pref., Japan
Chikama Clinic
🇯🇵Sapporo city, Hokkaido pref., Japan
Ino Hospital
🇯🇵Himeji city, Hyogo pref., Japan
Shimizu Clinic
🇯🇵Ise city, Mie pref., Japan
Center for Preventive Medical Treatment, NTT West Takamatsu Hospital
🇯🇵Takamatsu city, Kagawa pref., Japan
Osumi-Kanoya Hospital
🇯🇵Kanoya city, Kagoshima pref., Japan
Toshiba Rinkan Hospital
🇯🇵Sagamihara city, Kanagawa pref., Japan
Fukumura Clinic
🇯🇵Yokohama city, Kanagawa pref., Japan
Shinwakai Fukuda Iin
🇯🇵Yokohama city, Kanagawa pref., Japan
Yamashita Clinic
🇯🇵Amakusa city, Kumamoto pref., Japan
Koyasako iin
🇯🇵Kamimashiki gun, Kumamoto pref., Japan
Doi Naika-ichoka Clinic
🇯🇵Kumamoto city, Kumamoto pref., Japan
Yi Medical Clinic
🇯🇵Kumamoto city, Kumamoto pref., Japan
Universal Shipbuilding Co. Ariake Shipyard Ariake Infirmary
🇯🇵Tamana gun, Kumamoto pref., Japan
Sawai medical Clinic
🇯🇵Kyotanabe city, Kyoto pref., Japan
Higashiyama Takeda Hospital
🇯🇵Kyoto city, Kyoto pref., Japan
Sakazaki Clinic
🇯🇵Kyoto city, Kyoto pref., Japan
Shinya Clinic
🇯🇵Kyoto city, Kyoto pref., Japan
Tegoshi Clinic
🇯🇵Kyoto city, Kyoto pref., Japan
Iryohojin Yamamoto Naika
🇯🇵Nishisonogi gun, Nagasaki pref., Japan
Nakahori Iin
🇯🇵Kitakatsuragi gun, Nara pref., Japan
Saiseikai Nara Hospital
🇯🇵Nara city, Nara pref., Japan
Makiura Naika
🇯🇵Yamatokoriyama city, Nara pref., Japan
Medical Treatment Corporate Foundation Yubari Kibounomori Yubari City Clinic
🇯🇵Yubari city, Hokkaido pref., Japan
Katsuya Clinic
🇯🇵Amagasaki city, Hyogo pref, Japan
Dr. Hayakawa's Family Clinic
🇯🇵Kanazawa city, Ishikawa pref., Japan
Wakasa Medical Clinic
🇯🇵Kanazawa city, Ishikawa pref., Japan
Sugie Clinic
🇯🇵Iwate gun, Iwate pref., Japan
Hatori Medical Clinic
🇯🇵Kawasaki city, Kanagawa pref., Japan
Matsuo Naika Clinic
🇯🇵Yokohama city, Kanagawa pref., Japan
Miho-cho Cardiovascular Medical Clinic
🇯🇵Yokohama city, Kanagawa pref., Japan
Paula's Clinic
🇯🇵Yokohama city, Kanagawa pref., Japan
Suzuki Orthopedic Clinic
🇯🇵Yokohama city, Kanagawa pref., Japan
Hara Clinic
🇯🇵Yokosuka City, Kanagawa pref., Japan
Nakayama Cardiovascular Clinic
🇯🇵Amakusa city, Kumamoto pref., Japan
National Health Insurance Central Hospital Aso
🇯🇵Aso city, Kumamoto pref., Japan
Shono Heart Clinic
🇯🇵Kumamoto city, Kumamoto pref., Japan
Suizenji Tohya Hospital
🇯🇵Kumamoto city, Kumamoto pref., Japan
Gotoh Clinic
🇯🇵Kyoto city, Kyoto pref., Japan
Horii Clinic Kiodai
🇯🇵Nabari city, Mie pref., Japan
Kasahara Clinic
🇯🇵Kahihara city, Nara pref., Japan
Oosumi Naika Iin
🇯🇵Kashihara city, Nara pref., Japan
Ote Clinic of Internal Medicine
🇯🇵Sakurai city, Nara pref., Japan
Ishida Medical Clinic
🇯🇵Usa city, Oiat pref., Japan
Okyozuka Clinic
🇯🇵Ishikawa gun, Ishikawa pref., Japan
Murata Clinic
🇯🇵Kahoku gun, Ishikawa pref., Japan
Kawasaki Family Clinic
🇯🇵Ichinoseki, Iwate pref., Japan
Takamiya General Clinic
🇯🇵Shiwa gun, Iwate pref., Japan
Matsuoka Clinic
🇯🇵Kitakatsuragi gun, Nara pref., Japan
Nemoto G.I.M. Clinic
🇯🇵Ashigara-kami gun, Kanagawa pref., Japan
Medical Corp Takeda Clinic
🇯🇵Isehara city, Kanagawa pref., Japan
Hashimoto Clinic
🇯🇵Kamakura city, Kanagawa pref., Japan
Iroden Clinic
🇯🇵Kamakura city, Kanagawa pref., Japan
Yamamoto Clinic
🇯🇵Sagamihara city, Kanagawa pref., Japan
Miyoshi-Clinic
🇯🇵Yokohama city, Kanagawa pref., Japan
Shinyoshida Clinic
🇯🇵Yokohama city, Kanagawa pref., Japan
Yokohama Sotetsu bldg. clinic of internal medicine
🇯🇵Yokohama city, Kanagawa pref., Japan
Higashi Diabetes and Cardiovascular Clinic
🇯🇵Tamana city, Kumamoto pref., Japan
Takagi Cardiology Clinic
🇯🇵Kyoto city, Kyoto pref., Japan
Takenaka Clinic
🇯🇵Kyoto city, Kyoto pref., Japan
Shimoina Kosei Hospital
🇯🇵Shimoina gun, Nagano pref., Japan
Sawada Clinic
🇯🇵Kashiba city, Nara pref., Japan
Medical Corporation Kiriyama Clinic
🇯🇵Kashihara city, Nara pref., Japan
Takanohara Central Hospital
🇯🇵Nara city, Nara pref., Japan
Otsuka Internal Medicine Clinic
🇯🇵Marugame city, Kagawa pref., Japan
Yakushima Tokushukai Hospital
🇯🇵Kumage gun, Kagoshima pref., Japan
Magokoro Internal Medicine and Orthopedic Clinic
🇯🇵Ashigarakami gun, Kanagawa pref., Japan
Akizawa Clinic
🇯🇵Isehara city, Kanagawa pref., Japan
Kamakura Naika Shinryosyo
🇯🇵Kamakura city, Kanagawa pref., Japan
Minamisawa Clinic
🇯🇵Yokohama city, Kanagawa pref., Japan
Yokohama City University Medical Center
🇯🇵Yokohama city, Kanagawa pref., Japan
Ueta Medical Clinic
🇯🇵Kochi city, Kochi pref., Japan
Miyamoto Internal Clinic
🇯🇵Kikuchi city, Kumamoto pref., Japan
Yoshimura Jyunnkannkika Naika Iinn
🇯🇵Tamana city, Kumamoto pref., Japan
Miyagi Clinic Cardiovascular Medicine
🇯🇵Yatsushiro city, Kumamoto pref., Japan
Koide Iin
🇯🇵Kizugawa-city, Kyoto pref., Japan
Asamoto Clinic of Internal Medicine
🇯🇵Kyoto city, Kyoto pref., Japan
Hoshiko Clinic
🇯🇵Nagasaki city, Nagasaki pref., Japan
Yamada Clinic
🇯🇵Ota-ku, Tokyo, Japan
Sakaguchi Clinic
🇯🇵Sakurai city, Nara pref., Japan
Sano Clinic
🇯🇵Murakami city, Niigata pref., Japan
Watanabe NJ Clinic
🇯🇵Beppu city, Oiat pref., Japan
Hattori Clinic
🇯🇵Hachioji city, Tokyo, Japan
Ikeda Clinic
🇯🇵Higashiosaka city, Osaka pref., Japan
Ishiga Clinic
🇯🇵Ibaraki city, Osaka pref., Japan
Yoshida Clinic
🇯🇵Kaizuka city, Osaka pref., Japan
Iryouhoujin Suisyoukai Murata Hospital
🇯🇵Osaka city, Osaka pref., Japan
Matsushita Medical Clinic
🇯🇵Osaka city, Osaka pref., Japan
Matsuo Clinic
🇯🇵Yao city, Osaka pref., Japan
Enomoto Clinic
🇯🇵Ageo city, Saitama pref., Japan
Matsuta Heart Clinic
🇯🇵Yamatokoriyama city, Nara pref., Japan
Nakatani Clinic
🇯🇵Yamatotakada city, Nara pref., Japan
Maeda Medical Clinic
🇯🇵Niigata city, Niigata pref., Japan
Hirata Clinic
🇯🇵Oita city, Oiat pref., Japan
Tokumaru Digestive Internal Medicine Clinic
🇯🇵Oita city, Oiat pref., Japan
Hachiouji Naika Clinic
🇯🇵Kurashiki city, Okayama pref., Japan
Yuhara Naika Clinic
🇯🇵Okayama city, Okayama pref., Japan
Nishimura Clinic
🇯🇵Fujiidera city, Osaka pref., Japan
Ogawa Clinic
🇯🇵Higashiosaka city, Osaka pref., Japan
Masuda Clinic
🇯🇵Ibaraki city, Osaka pref., Japan
Medical Corporation Joukokai Teranishi-geka naika
🇯🇵Moriguchi city, Osaka pref., Japan
Keiju Hospital
🇯🇵Osaka city, Osaka pref., Japan
Kubota Clinic
🇯🇵Osaka city, Osaka pref., Japan
Nishizawa Clinic
🇯🇵Osaka city, Osaka pref., Japan
Osaka General Medical Center
🇯🇵Osaka city, Osaka pref., Japan
Senpuku Clinic
🇯🇵Osaka city, Osaka pref., Japan
Tai Internal Medicin Clinic
🇯🇵Osaka city, Osaka pref., Japan
Iryohojin Nogi Naika Iin
🇯🇵Suita city, Osaka pref., Japan
Medimo Hanyu Clinic
🇯🇵Hanyu city, Saitama pref., Japan
Iryohojin Hogi Shinryojo
🇯🇵Kawaguchi city, Saitama pref., Japan
Tokutake Iin
🇯🇵Kawaguchi city, Saitama pref., Japan
Gamo Tenjinbashi Clinic
🇯🇵Koshigaya city, Saitama pref., Japan
Iwatsuki-minami Hospital
🇯🇵Saitama city, Saitama pref., Japan
Izuoka Clinic
🇯🇵Osaka city, Osaka pref., Japan
Ichida Internal Clinic
🇯🇵Takaishi city, Osaka pref., Japan
Ryo Clinic
🇯🇵Takatsuki city, Osaka pref., Japan
Hirose Hospital
🇯🇵Kawagoe city, Saitama pref., Japan
Nashida naika clinic
🇯🇵Tokorozawa City, Saitama pref., Japan
Iryouhoujin Yuukoukai Morioka Naika Shonika
🇯🇵Oyama city, Tochigi pref., Japan
Takada Clinic
🇯🇵Tochigi city, Tochigi pref., Japan
Fukushima Clinic
🇯🇵Itano gun, Tokushima pref., Japan
Matsumura Internal, Gastrointestial Medicine
🇯🇵Tokushima city, Tokushima pref., Japan
Yokoi Internal Medicine
🇯🇵Tokushima city, Tokushima pref., Japan
Toyoizumi Hospital
🇯🇵Hachioji city, Tokyo, Japan
Utsugidai Tajima Clinic
🇯🇵Hachioji City, Tokyo, Japan
Tenjinmae Clinic
🇯🇵Mitaka city, Tokyo, Japan
Magari Clinic
🇯🇵Shinjuku ku, Tokyo, Japan
ISHII Medical Clinic
🇯🇵Tachikawa-shi, Tokyo, Japan
Medical Corporation Shibuya Clinic
🇯🇵Kumagaya city, Saitama pref., Japan
Yamamoto Naika Ityoka
🇯🇵Itano gun, Tokushima pref., Japan
Kitagawa Naika Ityoka
🇯🇵Tokushima city, Tokushima pref., Japan
Juntendo University Hospital
🇯🇵Bunkyo ku, Tokyo, Japan
Ono Heart Clinic
🇯🇵Koto ku, Tokyo, Japan
Shiba Palace Clinic
🇯🇵Minato-ku, Tokyo, Japan
Shizuoka Medical Alliance Shirahama Chuou Clinic
🇯🇵Shimoda city, Shizuoka pref., Japan
Aoshima Clinic
🇯🇵Shizuoka city, Shizuoka pref., Japan
Shizuoka Hospital
🇯🇵Shizuoka city, Shizuoka pref., Japan
Yuki National Health Insurance Hospital Of Minami Town
🇯🇵Kaifu gun, Tokushima pref., Japan
Sekishinkan Hospital
🇯🇵Komatsushima city, Tokushima pref., Japan
Kitasako Clinic
🇯🇵Tokushima city, Tokushima pref., Japan
Yata Clinic
🇯🇵Yoshinokawa city, Tokushima pref., Japan
Mochizuki Naika Clinic
🇯🇵Itabashi ku, Tokyo, Japan
Nishio Clinic
🇯🇵Itabashi ku, Tokyo, Japan
Kamada Clinic
🇯🇵Mitaka city, Tokyo, Japan
Matsumura Gastroenterological Clinic
🇯🇵Setagaya ku, Tokyo, Japan
Yotsuya Internal Medicine Clinic
🇯🇵Shinjuku ku, Tokyo, Japan
Honma Clinic
🇯🇵Sakata city, Yamagata pref., Japan
Yamagata Tokushukai Hospital
🇯🇵Yamagata city, Yamagata pref., Japan
Okagawa Clinic
🇯🇵Tokushima city, Tokushima pref., Japan
Choei Clinic
🇯🇵Edogawa ku, Tokyo, Japan
Yotsuya-Murakami Internal Medicine Clinic
🇯🇵Shinjuku ku, Tokyo, Japan
Sumidagawa Clinic
🇯🇵Sumida ku, Tokyo, Japan
Takahashi Ko Minako Clinic
🇯🇵Murayama city, Yamagata pref., Japan
Nihei Clinic
🇯🇵Yamagata city, Yamagata pref., Japan
Obanazawa City Clinic
🇯🇵Obanazawa city, Yamagata pref., Japan
Kuwahara Clinic
🇯🇵Iwakuni city, Yamaguchi pref., Japan
Higashikatsura Medical Clinic
🇯🇵Tsuru city, Yamanashi pref., Japan