NL-OMON55380
Recruiting
Not Applicable
Amyloid pathology in cognitively normal elderly subjects - PreclinAD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Alzheimer's disease
- Sponsor
- Vrije Universiteit Medisch Centrum
- Enrollment
- 200
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- Age 60\-100 years \- Monozygotic twin \- Telephone Interview for Cognitive
- •Status modified (TICSm) \>22 \- Geriatric Depression Scale (GDS) (15 item) \<11 \-
- •Consortium to Establish a Registry for Alzheimer\*s Disease (CERAD) 10 word list
- •immediate and delayed recall (\> \-1\.5 SD of age adjusted normative data) \-
- •Clinical Dementia Rating (CDR) scale of 0 with a score on the memory subdomain
Exclusion Criteria
- •\- clinical diagnosis of probable Alzheimer's disease or mild cognitive
- •\- neurological problems like Parkinson's disease, Huntington disease, severe
- •head trauma, braintumour, stroke with physical impairment, epilepsy currently
- •using antiepileptic drugs, braininfection
- •\- known uncontrolled diabetes, thyroid disease, vitamin B12 deficiency
- •\- psychiatric disorder like psychosis or schizophrenia
Outcomes
Primary Outcomes
Not specified
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