Effect of Vitamin E in treatment resistant Epilepsy

Completed

• Conditions: Epilepsy and recurrent seizures, (2) ICD-10 Condition: G404||Other generalized epilepsy and epileptic syndromes,

• Registration Number: CTRI/2018/08/015275
• Lead Sponsor: Muhammed Shabeer P

Brief Summary

Vitamin E is a antioxidant , oxidative stress is important pathogen for epilepsy and many of anti epileptic drugs produces oxidative stress, so vitamin E can act here.

Here Vitamin E is supplementing to treatment resistant epilepsy in addition to anticoagulant drugs for 6 months , study the outcomes like reduction in seizure episodes, relation with antiepileptic drugs and also side effects of vitamin E if any. EEG will be recorded before and after study.

Study completed,  concluded that Vitamin helpful in reducing the number seizure lasting more than 5 min ( impending status).

No significant change in number seizure , EEG changes , antiepileptic drugs after supplementing vitamin E to children with treatment resistant epilepsy

Detailed Description

Not available

Study Timeline

• Study Start: 2018-08-16
• Study Completion: 2019-11-30
• Last Update Posted: 2021-12-08

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Age 1-12 years Diagnosis of treatment resistant epilepsy A) Recieving any of at least two anti convulsant drugs for past 6 months B) at least 3 seizures in last 6 months C) the ability of family or friends to count the number of seizures in epileptic patients during the determined period.

Exclusion Criteria

Neuroimaging suggestive of mass lesion Receiving vitamin E supplementation within 6 months of study Presence of live and kidney disease.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To study effect of Vitamin E supplementation in the reduction of seizure episodes in treatment resistant epilepsy patients on antiepileptuc drugs	6 months

Secondary Outcome Measures

Name	Time	Method
To study seizure episode reduction in different types of seizure in Vitamin E supplemented children	To study correlation of vitamin E supplementation and reduction of seizure episodes with different antiepileptic drugs

Trial Locations

Locations (1)

GMCH Aurangabad; 🇮🇳 Aurangabad, MAHARASHTRA, India

GMCH Aurangabad

🇮🇳Aurangabad, MAHARASHTRA, India

Muhammed Shabeer P

Principal investigator

9562028461

mohdshabeerp@gmail.com