Role of Inflammation in Carpal Tunnel Syndrome: A Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- The relationship between inflammatory markers and pinch strength of CTS patients.
研究概览
简要总结
This study aims to investigate the role of inflammation in carpal tunnel syndrome (CTS) using a prospective cohort study design. The study will involve a sample of at least 50 individuals with CTS who will undergo a comprehensive clinical and biochemical evaluation to assess the role of inflammation in CTS. The primary outcome measures include inflammatory markers, such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), as well as clinical measures of CTS severity. Data will be analyzed using regression analysis to determine the relationship between inflammation and CTS. The study is expected to provide information on the role of inflammation in CTS and inform the choice of drug and concentration for transdermal drug administration.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Individuals aged 18 years or older
- •Diagnosis of carpal tunnel syndrome based on clinical symptoms and nerve conduction studies
- •Willingness and ability to provide informed consent to participate in the study
- •Willingness and ability to comply with study procedures and follow-up visits
排除标准
- •Presence of other neurological conditions that may affect nerve function in the upper extremities
- •Use of medications that may affect inflammation or carpal tunnel syndrome severity
- •History of previous carpal tunnel release surgery on the affected wrist
- •Inability to comply with study procedures or follow-up visits
- •Pregnancy or breastfeeding
结局指标
主要结局
The relationship between inflammatory markers and pinch strength of CTS patients.
时间窗: Changes of inflammatory markers and pinch strength at baseline, 4 weeks, 8 weeks, and 12 weeks after baseline
interleukin-6, tumor necrosis factor-alpha using blood tests. pinch strength will be measured using a dynamometer
The relationship between inflammatory markers and nerve conduction study of patients with CTS
时间窗: Changes of inflammatory markers and nerve conduction study at baseline, 4 weeks, 8 weeks, and 12 weeks after baseline
interleukin-6, tumor necrosis factor-alpha using blood tests. Nerve conduction study results (motor and sensory distal latency of median nerve and amplitude) will be used to determine CTS severity based on Bland's grading scale.
The relationship between inflammatory markers and symptom severity of carpal tunnel syndrome (CTS).
时间窗: Changes of inflammatory markers and symptoms severity at baseline, 4 weeks, 8 weeks, and 12 weeks after baseline
interleukin-6, tumor necrosis factor-alpha using blood tests. Symptom severity will be assessed with standardized questionnaire "the Boston Carpal Tunnel Questionnaire".
The relationship between inflammatory markers and grip strength of patients with CTS.
时间窗: Changes of inflammatory markers and grip strength at baseline, 4 weeks, 8 weeks, and 12 weeks after baseline
interleukin-6, tumor necrosis factor-alpha using blood tests. functional status by grip strength using a dynamometer.
次要结局
未报告次要终点
研究者
Mohamed Magdy ElMeligie
Lecturer of Physical Therapy and Director of Electromyography Lab
Ahram Canadian University