Role of Inflammation in Carpal Tunnel Syndrome

Not yet recruiting

• Conditions: Median Neuropathy, Carpal Tunnel; Carpal Tunnel Syndrome

• Registration Number: NCT05852288
• Lead Sponsor: Ahram Canadian University

Brief Summary

This study aims to investigate the role of inflammation in carpal tunnel syndrome (CTS) using a prospective cohort study design. The study will involve a sample of at least 50 individuals with CTS who will undergo a comprehensive clinical and biochemical evaluation to assess the role of inflammation in CTS. The primary outcome measures include inflammatory markers, such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), as well as clinical measures of CTS severity. Data will be analyzed using regression analysis to determine the relationship between inflammation and CTS. The study is expected to provide information on the role of inflammation in CTS and inform the choice of drug and concentration for transdermal drug administration.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-04-19
• Status Verified: 2023-05
• Study First Submitted QC: 2023-05-01
• Last Update Submitted: 2023-05-01
• Study First Posted: 2023-05-10
• Last Update Posted: 2023-05-10
• Study Start: 2023-05-15
• Primary Completion: 2023-09-01
• Study Completion: 2023-09-15

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Individuals aged 18 years or older
• Diagnosis of carpal tunnel syndrome based on clinical symptoms and nerve conduction studies
• Willingness and ability to provide informed consent to participate in the study
• Willingness and ability to comply with study procedures and follow-up visits

Exclusion Criteria

• Presence of other neurological conditions that may affect nerve function in the upper extremities
• Use of medications that may affect inflammation or carpal tunnel syndrome severity
• History of previous carpal tunnel release surgery on the affected wrist
• Inability to comply with study procedures or follow-up visits
• Pregnancy or breastfeeding

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The relationship between inflammatory markers and pinch strength of CTS patients.	Changes of inflammatory markers and pinch strength at baseline, 4 weeks, 8 weeks, and 12 weeks after baseline	interleukin-6, tumor necrosis factor-alpha using blood tests. pinch strength will be measured using a dynamometer
The relationship between inflammatory markers and nerve conduction study of patients with CTS	Changes of inflammatory markers and nerve conduction study at baseline, 4 weeks, 8 weeks, and 12 weeks after baseline	interleukin-6, tumor necrosis factor-alpha using blood tests. Nerve conduction study results (motor and sensory distal latency of median nerve and amplitude) will be used to determine CTS severity based on Bland's grading scale.
The relationship between inflammatory markers and symptom severity of carpal tunnel syndrome (CTS).	Changes of inflammatory markers and symptoms severity at baseline, 4 weeks, 8 weeks, and 12 weeks after baseline	interleukin-6, tumor necrosis factor-alpha using blood tests. Symptom severity will be assessed with standardized questionnaire "the Boston Carpal Tunnel Questionnaire".
The relationship between inflammatory markers and grip strength of patients with CTS.	Changes of inflammatory markers and grip strength at baseline, 4 weeks, 8 weeks, and 12 weeks after baseline	interleukin-6, tumor necrosis factor-alpha using blood tests. functional status by grip strength using a dynamometer.

Trial Locations

Locations (1)

Outpatient clinic of faculty of physical therapy, Ahram Canadian University; 🇪🇬 Al Ḩayy Ath Thāmin, Giza, Egypt