Effect of lying in the prone position on blood pressure in women with preeclampsia, women with gestational hypertension and healthy pregnant wome

Not Applicable

Completed

• Conditions: Hypertension; Preeclampsia; Gestational hypertension; Pregnancy; Cardiovascular - Hypertension; Reproductive Health and Childbirth - Fetal medicine and complications of pregnancy

• Registration Number: ACTRN12615000160538
• Lead Sponsor: The Royal Womens Hospital Parkville

Brief Summary

This study revealed that the prone position is a comfortable and viable position for women with preeclampsia. The prone position reduced systolic blood pressure in term pregnant healthy and women with preeclampsia without obvious unwanted side effects. Prone positioning could be used as an acute treatment for preeclampsia and may reduce the development of preeclampsia if used early in pregnancy. Further research is needed.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-02-18
• Study Completion: 2018-10-20
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 65

Inclusion Criteria

Healthy pregnant women:
Healthy term (greater than or equal to 37 weeks gestation) pregnant women will be defined as American Society of Anesthesiologists (ASA) Classification I or II, with no significant medical or surgical illness. Age 18-45 years
Women with gestationally acquired hypertension greater than or equal to 20 weeks gestation:
Women aged 18-45 years will be included in the study if they meet the diagnostic criteria for either gestational hypertension or preeclampsia.

Exclusion Criteria

Healthy pregnant women:
current vasoactive medication including salbutamol and thyroxine, pre-existing or gestational diabetes, known cardiovascular disease including chronic disorders that may influence the cardiovascular system such as chronic renal disease, multiple pregnancy, smokers, any woman in labour or postpartum and inability to consent to study. Age < 18, > 45 years
Women with gestationally acquired hypertension:
Any woman with pre-existing or gestational diabetes, multiple pregnancy, smokers, any woman in labour, any woman with decompensated disease (eclampsia, pulmonary oedema) or postpartum and inability to consent to study, Age < 18, > 45 years

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
blood pressure change using an automatic sphygmomanometer[ after five minutes of resting in the left lateral position and after five minutes of resting in the prone position]

Secondary Outcome Measures

Name	Time	Method
heart rate measured by an ECG in the left lateral and in the prone position[ after five minutes of resting in the left lateral and in the prone position];respiratory rate, measured by an investigator counting the respiratory rate, in the left lateral and in the prone position[ after five minutes of resting in the left lateral and in the prone position];cardiac output obtained by echocardiography in the left lateral and in the prone position[ after five minutes of resting in the left lateral and in the prone position];Oxygen saturation, as measured by a pulse oximeter placed on the finger, after resting in the left lateral and in the prone position[ after resting in the left lateral and in the prone position for five minutes ]