Development of the Effectiveness of Rehabilitation Tools for Neurovisual Disorders in Patients With Posterior Cortical Atrophy

Not Applicable

Completed

• Conditions: Posterior Cortical Atrophy
• Interventions: Behavioral: Recognition of objects; Behavioral: Location of objects; Behavioral: Manipulation of objects

• Registration Number: NCT04041089
• Lead Sponsor: Centre Hospitalier Universitaire de Nice

Brief Summary

Posterior cortical atrophy (PCA) is manifested by neuro-visual disorders that alter the spatial location of objects, their manipulation and/or recognition. Its etiology is most often neurodegenerative, with a major impact on the autonomy and mood of patients and their families. Few studies have focused on non-medication management of these disorders.

The present study thus has a double objective: the development of a complete tool to work on the recognition, localization and/or manipulation of objects; and the evaluation of the effectiveness of this type of management.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2019-07-30
• Study First Submitted QC: 2019-07-30
• Study First Posted: 2019-08-01
• Study Start: 2019-09-02
• Primary Completion: 2021-06-15
• Study Completion: 2022-06-15
• Status Verified: 2023-02
• Last Update Submitted: 2023-03-21
• Last Update Posted: 2023-03-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 3

Inclusion Criteria

• Age >50 years old
• Male or Female
• Patients with a diagnosis of PCA according to the criteria of Tang-Wai et al (2004)
• MMS>15
• Voluntary, written and informed consent of the patient himself or its legal representative (guardian/curator), with oral consent of the patient in all cases
• Anti-Alzheimer's and psychotropic treatments stable for one month, if taken by the patient
• Affiliation to a social security system

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Exclusion Criteria

• Uncorrected visual disorders with non-degenerative etiology (AV<0.5)
• Person under the protection of justice
• Pregnant women (a pregnancy test will be performed in premenopausal women)

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Recognition of objects	Recognition of objects	Patients will do the therapy in the following order: object location, object manipulation and object recognition
Location of objects	Location of objects	Patients will do the therapy in the following order: object recognition, object location, and object manipulation
Manipulation of objects	Manipulation of objects	Patients will do the therapy in the following order: object manipulation, object recognition and object location

Primary Outcome Measures

Name	Time	Method
Effectiveness evaluation	At week 34	Effectiveness will be evaluated a score based on success rate (from 0 to 10), reaction time and eye-recording .

Trial Locations

Locations (1)

Institut Claude Pompidou - Centre Mémoire de Ressources et de Recherche du CHU de Nice; 🇫🇷 Nice, Alpes-Maritime, France