Effectiveness of injection hyperbaric bupivacaine(0.5%) and injection hyperbaric levobupivacaine(0.5%) in caserean section under subarachnoid block: double blinded randomised controlled trial.(Dissertation Work)
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- Better hemodynamic stability of injection hyperbaric levobupivacaine , early recovery of sensory and motor sensation
研究概览
简要总结
• Subarachnoid block is the most commonly used technique for cesarean delivery due to following advantages compared to general anaesthesia[1].
-It is easily performed and provides a rapid onset of sensory and motor block.
- It has good muscle relaxion property with added advantagelike preventing airway manipulation, pressor response from intubation, sore throat, excessive sedation.
- It also help to early establishment of mother baby bond.
• Till date racemic mixture Bupivacaine is most commonly used drug for caserean section but with introduction of newer local anaesthetics which are purely S-enantiomer like Ropivacaine and Levobupivacaine which are having minimal side effect (less cardiotoxic and less neurotoxic), these can be use with increased safety[2].
• Levobupivacaine is a long-acting amino amide belongs to family n-alkyl substitute Pipecoloxylidide[4].
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- Female
入选标准
- •Patient undergoing caserean section under subarachnoid block Age 18 to 40 year ASA grade 1/2/3.
排除标准
- •Pr having history to study drugs.
结局指标
主要结局
Better hemodynamic stability of injection hyperbaric levobupivacaine , early recovery of sensory and motor sensation
时间窗: During intra op, and till sensory motor recovery, 4hr after lscs
次要结局
- early recovery of sensory and motor block(At 1h, 2hr, 3 hr, 4hr)
- Early recovery of sensory and motor sensation(From onset of effect)