Integrity of the Mucosa: effect of Amino acid formula on Gastrointestinal tract epithelium in adult Eosinophilic esophagitis patients - IMAGE trial

Academisch Medisch Centrum0 个研究点目标入组 31 人开始时间: 待定最近更新: 2024年4月23日

试验速览

暂无简介。

•- Previous diagnosis of EoE confirmed by histopathology e.g. presence of >15 eosinophilic granulocytes per high power field (hpf) in mid or proximal esophageal biopsies before the start of any therapy
•- Currently experiencing dysphagia
•- Written informed consent
•- Age 18 * 75 years;Healthy controls:
•- Written informed consent
•- Age 18 * 75 years

•- Inability to stop topical corticosteroids
•- Use of systemic corticosteroids, leukotriene inhibitors, or monoclonal antibodies, in the month preceding the study
•- Use of anticoagulants at study entry
•- Use of NSAIDs without possibility to stop
•- History of peptic ulcer disease
•- History of Barrett*s esophagus
•- History of GI cancer
•- History of GI tract surgery (except appendectomy)
•- ASA class IV or V
•-History of sacharase-isomaltase deficiency
•-History of hereditary fructose-intolerance, galactosemy or lactose deficiency
•-History of diabetes mellitus
•-Hypersensitivity to mannitol or lactulose;Healthy controls:
•- Use of systemic corticosteroids, leukotriene inhibitors, or monoclonal antibodies in the month preceding the study
•- Use of anticoagulants at study entry
•- Use of NSAIDs without possibility to stop
•- Personal history of atopic, skin or systemic diseases
•- Symptoms suggestive of esophageal disease
•- History of GI cancer
•- History of GI tract surgery (except appendectomy)
•- History of PPI, H2-receptor antagonist, or prokinetic drug use
•- ASA class IV or V
•-Hypersensitivity to mannitol or lactulose
•-History of sacharase-isomaltase deficiency
•-History of hereditary fructose-intolerance, galactosemy or lactose deficiency
•-History of diabetes mellitus

发起方