Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia
Overview
- Phase
- Early Phase 1
- Intervention
- Propranolol
- Conditions
- Aging
- Sponsor
- University of Missouri-Columbia
- Enrollment
- 75
- Locations
- 1
- Primary Endpoint
- Forearm blood flow
- Status
- Recruiting
- Last Updated
- 7 months ago
Overview
Brief Summary
The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.
Investigators
Jacqueline K Limberg, PhD
Associate Professor
University of Missouri-Columbia
Eligibility Criteria
Inclusion Criteria
- •Female assigned at birth
- •Pre, peri- or post-menopausal
- •Healthy weight (BMI ≥18 and ≤30 kg/m2)
Exclusion Criteria
- •Male (assigned at birth)
- •Pregnancy, breastfeeding
- •Use of hormone replacement therapies
- •Hysterectomy
- •Body mass index \>30 kg/m2
- •Diagnosed sleep apnea
- •Current smoking/Nicotine/Drug use
- •Nerve/neurologic disease
- •Cardiovascular, hepatic, renal, respiratory disease
- •Blood pressure ≥140/90 mmHg
Arms & Interventions
Cold pressor test
Participants will be exposed to the cold pressor test (ice water on the foot).
Intervention: Propranolol
Cold pressor test
Participants will be exposed to the cold pressor test (ice water on the foot).
Intervention: Placebo
Hypoxia
Participants will be exposed to hypoxia (low oxygen air) using a mask.
Intervention: Placebo
Hypoxia
Participants will be exposed to hypoxia (low oxygen air) using a mask.
Intervention: Propranolol
Hypoxia
Participants will be exposed to hypoxia (low oxygen air) using a mask.
Intervention: Gemtesa
Cold pressor test
Participants will be exposed to the cold pressor test (ice water on the foot).
Intervention: Gemtesa
Hypercapnia
Participants will be exposed to hypercapnia (high carbon dioxide air) using a mask.
Intervention: Placebo
Hypercapnia
Participants will be exposed to hypercapnia (high carbon dioxide air) using a mask.
Intervention: Propranolol
Hypercapnia
Participants will be exposed to hypercapnia (high carbon dioxide air) using a mask.
Intervention: Gemtesa
Outcomes
Primary Outcomes
Forearm blood flow
Time Frame: Change from baseline to 5 minutes.
Blood flow in the forearm measured with venous occlusion plethysmography.