Evaluating Pain Control Strategies in Postpartum Patients on Opioid Use Disorder Medications: Efficacy and Safety Outcomes.
Overview
- Phase
- Early Phase 1
- Intervention
- Regional Anesthesia
- Conditions
- Substance Use Disorder (SUD)
- Sponsor
- Medical College of Wisconsin
- Enrollment
- 20
- Locations
- 2
- Primary Endpoint
- Number of participants with Change in pain assessment scores from baseline post surgery
- Status
- Recruiting
- Last Updated
- 6 months ago
Overview
Brief Summary
The purpose of this study is to investigate the efficacy of three different modalities of post-operative pain control in parturient with opioid use disorders. The investigators aim to determine whether the different approach utilized show better outcomes with pain management and if there are any association with reduction of symptoms of anxiety, depression, and overall well-being.
Investigators
Christopher Fadumiye
Assistant Professor
Medical College of Wisconsin
Eligibility Criteria
Inclusion Criteria
- •Inclusion criteria include being a parturient with Substance use disorder (SUD) and age 18-35
Exclusion Criteria
- •Exclusion criteria include having a diagnosed medical condition(allergies to medication, pathology such as severe aortic stenosis excluding patients from receiving an epidural etc) that will exempt patient from intervention arm of the study.
Arms & Interventions
Transverse abdominal Plane(TAP) Block with long acting Exparel
A subset of participants (n=15) will be divided into three different arms: A.) Postoperative Epidural infusion for 24-36hrs B.) Hydromorphone Patient Controlled Analgesia (PCA) with Preservative free Morphine via epidural for 36hrs C.) Transverse abdominal Plane(TAP) Block with long acting Exparel.
Intervention: Regional Anesthesia
Postoperative Epidural infusion for 24-36hrs
A subset of participants (n=15) will be divided into three different arms: A.) Postoperative Epidural infusion for 24-36hrs B.) Hydromorphone Patient Controlled Analgesia (PCA) with Preservative free Morphine via epidural for 36hrs C.) Transverse abdominal Plane(TAP) Block with long acting Exparel.
Intervention: Epidural local anesthetic infusion
Hydromorphone Patient Controlled Analgesia (PCA),Preservative free Morphine via epidural for 36hrs
A subset of participants (n=15) will be divided into three different arms: A.) Postoperative Epidural infusion for 24-36hrs B.) Hydromorphone Patient Controlled Analgesia (PCA) with Preservative free Morphine via epidural for 36hrs C.) Transverse abdominal Plane(TAP) Block with long acting Exparel.
Intervention: Hydromorphone Patient Controlled Analgelsic
Outcomes
Primary Outcomes
Number of participants with Change in pain assessment scores from baseline post surgery
Time Frame: immediately after the study intervention and up to post op day 2
Number of participants with significant change in pain assessment scores and any association with reduction of symptoms of anxiety, depression, and overall well-being.