Endothelial Function Study Before Cardiovascular Surgery in COPD and/or SAS Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD)
- Sponsor
- University Hospital, Grenoble
- Enrollment
- 109
- Locations
- 3
- Primary Endpoint
- The primary endpoint is the percent of peripheral arterial tone (PAT) in COPD and/or OSAS patients compared to non COPD non OSAS patients.
- Status
- Terminated
- Last Updated
- 3 years ago
Overview
Brief Summary
The aim of this clinical trial is to evaluate the effect of chronic obstructive pulmonary disease (COPD) and/or obstructive sleep apnea syndrome (OSAS) on the endothelial function, before cardiovascular surgery, compared to non COPD non OSAS patients undergoing also a cardiovascular surgery, by an observational physiological study.
An interim analysis will be performed when 100 patients will be included.
Detailed Description
Secondary objectives of this clinical trial : * To evaluate the effect of COPD and/or OSAS on the systemic inflammation, insulin-resistance and oxydative stress, in comparison with non COPD non OSAS patients. * To evaluate the effect of COPD and/or OSAS on the inflammation and oxydative stress of the adipose tissue, in comparison with non COPD non OSAS patients. * To validate the STOP-BANG questionnaire in patients undergoing a cardiovascular surgery
Investigators
Eligibility Criteria
Inclusion Criteria
- •Men or women between 18 and 80 years old
- •Patient with planned coronary artery bypass graft surgery
- •Patient with planned peripheral vascular surgery
- •Patient with aortic surgery
Exclusion Criteria
- •Patient with aortic or mitral valvular replacement
- •Patient with emergency peripheral valvular surgery
- •Patient with emergency coronary artery bypass graft surgery
- •Patient with evolutive malignancy disease
- •Pregnant or lactating women
- •Patient with inadvisable bronchodilator (used for functional respiratory) exploration
Outcomes
Primary Outcomes
The primary endpoint is the percent of peripheral arterial tone (PAT) in COPD and/or OSAS patients compared to non COPD non OSAS patients.
Time Frame: one week before their cardiovascular surgery
Secondary Outcomes
- Evaluation of the systemic inflammation, insulin-resistance and oxidative stress occurring during COPD and/or OSAS patients compared to non COPD non OSAS patients.(one week before their cardiovascular surgery)
- Evaluation of adipose tissue inflammation and oxidative stress occurring during COPD and/or OSAS patients compared to non COPD non OSAS patients.(one week before their cardiovascular surgery)
- Polysomnography(one week before their cardiovascular surgery)
- Functional respiratory exploration(one week before their cardiovascular surgery)