Predictive markers for individualized biology-driven treatment for esophageal cancer

Recruiting

• Conditions: esophageal cancer; esophageal carcinomas; 10017991

• Registration Number: NL-OMON47729
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 180

Inclusion Criteria

All patients with esophageal cancer that undergo endoscopic ultrasound for
disease stageing.

Exclusion Criteria

Patients with PT-INR/PTT >1.5

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Study the relationship between genome-wide genetic and epigenetic alterations<br /><br>as well as characteristics of the tumor immune microenvironment of esophageal<br /><br>carcinomas and the association with disease free and progression free survival<br /><br>in order to identify biomarkers for response to treatment. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Study the relationship between genome-wide genetic and epigenetic alterations<br /><br>as well as characteristics of the tumor immune microenvironment of in<br /><br>esophageal carcinomas and the association to prognosis. Thereby we hope to<br /><br>identify a molecular alteration or profile that is associated with a high risk<br /><br>of distant metastasis.</p><br>