Developmental Language Difficulties: Behavioural and Electrophysiological Studies

Completed

• Conditions: Dysphasia; Dyslexia
• Interventions: Behavioral: auditory lexical decision task; Device: electroencephalogram

• Registration Number: NCT02872870
• Lead Sponsor: Lille Catholic University

Brief Summary

This study will help to better characterize oral and written language disorders and determine if these disorders are continuous or not. The participants ( dyslexic and dysphasic patients and control adults) will carry out an auditory lexical decision task during which an electroencephalogram (EEG) will be recorded.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03
• Primary Completion: 2015-03
• Study Completion: 2016-06
• Status Verified: 2016-08
• Study First Submitted: 2016-08-16
• Study First Submitted QC: 2016-08-16
• Last Update Submitted: 2016-08-16
• Study First Posted: 2016-08-19
• Last Update Posted: 2016-08-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 196

Inclusion Criteria

Not provided

Exclusion Criteria

• Mother tongue other than French
• Non-verbal reasoning abilities below 85 measured by the WISC 4 (for patients only) and Non-verbal capacities of reasoning lower than the normal measured by the non-verbal scale of Wechsler (for controls only)
• Presence of pervasive developmental disorders
• No affiliation to a social security regimen
• Absence of signature of the informed consent
• Subject of less than 8 years

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Dysphasic patients	electroencephalogram	lexical tests
Control adults	auditory lexical decision task	lexical tests and electroencephalogram (EEG).
Dyslexic patients	auditory lexical decision task	lexical tests
Dyslexic patients	electroencephalogram	lexical tests
Dysphasic patients	auditory lexical decision task	lexical tests
Control adults	electroencephalogram	lexical tests and electroencephalogram (EEG).

Primary Outcome Measures

Name	Time	Method
Score Alouette reading test	at inclusion	In this test, the participant has to read in a loud voice a text, during three minutes. The final score takes into account the speed and the number of errors. For test performance, clinical groups will be compared with its controls.
Score EVALEC reading test	at inclusion	For test performance, clinical groups will be compared with its controls.
Score silence reading test	at inclusion	A group of letters will be presented and the participant has to say if this letters compose a known word. For test performance, clinical groups will be compared with its controls.
Score of reading comprehension test	at inclusion	For test performance, clinical groups will be compared with its controls.
Score of Khomsi	at inclusion	The objective of this group of different tests is to evaluate comprehension and production of oral language. For test performance, clinical groups will be compared with its controls.

Secondary Outcome Measures

Name	Time	Method
Measure of the electroencephalography power spectra	at inclusion	For test performance, clinical groups will be compared with its controls.
Correlation between electroencephalography power spectra and clinical outcome	at inclusion	For test performance, clinical groups will be compared with its controls.

Trial Locations

Locations (3)

Hôpital Saint Vincent de Paul (GHICL); 🇫🇷 Lille, France

Université catholique de Louvain (IPSY); 🇧🇪 Louvain-la-Neuve, Belgium

Université de Lille 3 Charles de Gaulle (URECA); 🇫🇷 Villeneuve d'Ascq, France